| A Morphometric Study of the Lungs after Blast lnjury in Rats |
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| 作者姓名： | 赵敏 王正国 刘大维 张清华 王声文 周萍 |
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| 作者单位： | Department No.4 Research Institute of Surgery，Third Military Medical College，Chongqing，Department No.4，Research Institute of Surgery，Third Military Medical College，Chongqing，Department No.4，Research Institute of Surgery，Third Military Medical College，Chongqing，Department No.4，Research Institute of Surgery，Third Military Medical College，Chongqing，Department No.4，Research Institute of Surgery，Third Military Medical College，Chongqing，Department No.4，Research Institute of Surgery，Third Military Medical College，Chongqing |
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| 摘 要： | A lot of research work has been carriod out on thc lungs after blast injury, but nomorphomctric study of the blast-injured lungs has ever been reported so far.The authors quantifiedthe morphological changes of the lungs with blast injury in rats with stereological methods.t wasfound that following the blast injury,the pulmonary capillary volume and the intcmal surface arca de-creased significantly,while the arithmetic and harmonic mean thickness of the air-blood barrier andthe volume of polymorphonuclear leucocytes and platelets in the capillaries incrcased markedly.Themorphometric oxygen diffusion capacity of the lungs was remarkably reduced mainly due to the de-crease of the conductance of the air-blood barrier and erythrocytcs.In addition,the changes of theoxygen diffussion capacity of the lungs were closely related to the partial pressure of arteria/blood oxy-gen.These facts imply that the damage to the pulmonary capillaries was one of the main causes ofalveolar bleeding and early respiratory insufficiency.It is possible that a mathematic relationshipcould be established between the intensity of the blast impact and the consequent morphologicalchanges of the injured lungs.
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A Morphometric Study of the Lungs after Blast lnjury in Rats |
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| Zhao Min Wang Zhengguo Liu Daiwei Zhang Qinghua Wang Shengwen Zhou Ping.A Morphometric Study of the Lungs after Blast lnjury in Rats[J].Journal of Medical Colleges of PLA(China),1989(2). |
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| Authors: | Zhao Min Wang Zhengguo Liu Daiwei Zhang Qinghua Wang Shengwen Zhou Ping |
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| Institution: | Zhao Min Wang Zhengguo Liu Daiwei Zhang Qinghua Wang Shengwen Zhou Ping Department No.4,Research Institute of Surgery,Third Military Medical College,Chongqing |
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| Abstract: | A lot of research work has been carriod out on thc lungs after blast injury, but no morphomctric study of the blast-injured lungs has ever been reported so far.The authors quantified the morphological changes of the lungs with blast injury in rats with stereological methods.t was found that following the blast injury,the pulmonary capillary volume and the intcmal surface arca de- creased significantly,while the arithmetic and harmonic mean thickness of the air-blood barrier and the volume of polymorphonuclear leucocytes and platelets in the capillaries incrcased markedly.The morphometric oxygen diffusion capacity of the lungs was remarkably reduced mainly due to the de- crease of the conductance of the air-blood barrier and erythrocytcs.In addition,the changes of the oxygen diffussion capacity of the lungs were closely related to the partial pressure of arteria/blood oxy- gen.These facts imply that the damage to the pulmonary capillaries was one of the main causes of alveolar bleeding and early respiratory insufficiency.It is possible that a mathematic relationship could be established between the intensity of the blast impact and the consequent morphological changes of the injured lungs. |
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| Keywords: | blast injury lung morphornetry oxygcn diffusion capacity |
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