| 慢性乙型肝炎病毒表面抗原e大蛋白检测的临床意义 |
| |
| 引用本文： | 徐丛荣,魏建威,郑登滋,叶火铨.慢性乙型肝炎病毒表面抗原e大蛋白检测的临床意义[J].检验医学与临床,2010,7(8):673-675. |
| |
| 作者姓名： | 徐丛荣 魏建威 郑登滋 叶火铨 |
| |
| 作者单位： | 福建中医学院附属第二人民医院检验科,福州,350003 |
| |
| 摘 要： | 目的通过检测乙型肝炎(下称乙肝)患者血清中乙肝病毒(HBV)表面抗原大蛋白(LHBS)、HBV-DNA、HBV-preS1、乙肝病毒e抗原(HBeAg),探讨LHBS与后3者的相关性及LHBS在乙型肝炎诊治中的临床意义。方法LHBS、HBV-preS1、HBeAg采用酶联免疫吸附试验(ELISA)检测,HBV-DNA的检测方法为荧光定量聚合酶链反应(PCR)。结果91例HBV感染者血清中,LHBS的OD值与HBV-DNA拷贝数对数值具有良好的正相关性(rs=0.652,P0.01),LHBS与HBV-DNA、HBV-preS1、HBeAg间均相关(P0.01),且阳性率均存在差异有统计学意义(P0.05),LHBS的阳性率最高。在HBV-DNA阳性和HBV-DNA阴性组中,LHBS与HBeAg阳性率均存在差异有统计学意义,LHBS与HBV-preS1的阳性率在HBV-DNA阴性组中差异有统计学意义,LHBS更为敏感。在HBeAg阴性组中,LHBS与HBV-preS1、HBV-DNA的阳性率均存在差异有统计学意义,较HBV-preS1、HBV-DNA均高。结论LHBS是反映HBV感染者体内病毒复制程度的敏感、可靠指标。
|
| 关 键 词： | 乙型肝炎病毒 大蛋白 乙肝病毒DNA 乙肝病毒前S1抗原 |
Clinical significance of LHBS in patients with chronic hepstisis B |
| |
| XU Cong-rong,WEI Jiang-wei,ZHENG Deng-zi,YE Huo-quan.Clinical significance of LHBS in patients with chronic hepstisis B[J].Laboratory Medicine and Clinic,2010,7(8):673-675. |
| |
| Authors: | XU Cong-rong WEI Jiang-wei ZHENG Deng-zi YE Huo-quan |
| |
| Institution: | .(Department of Clinical Laboratory ,Second People＇s Hospital of Fujian Province Fuzhou Fujian 350003, China) |
| |
| Abstract: | Objective To discuss the correlation of hepatitis B virus large surface protein (LHBS)and HBeAg,HBV-DNA and HBV-preS1 and to discover the clinical significance of hepatitis B virus large surface protein in the diagnosis and treatment of patients with chronic hepstisis B.Methods LHBs and HBeAg were detected by enzyme-1inked immunosorbent assay(ELISA)while HBV-DNA by quantitative fluorescent PCR.Results In 91 serum samples. the OD value of serum LHBS was positively correlated with HBV-DNA copies(rs =0.652,P<0... |
| |
| Keywords: | hepatitis B virus large surface protein hepatitis B virus DNA hepatitis B virus preS1 antigen hepatitis B e antigen |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
