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艾灸治疗膝骨关节炎随机对照初步临床试验（英文）
引用本文：任秀梅,曹锦瑾,沈雪勇,王丽祯,赵玲,吴凡,张海蒙.艾灸治疗膝骨关节炎随机对照初步临床试验（英文）[J].世界针灸杂志,2012,22(2):28-33.
作者姓名：任秀梅  曹锦瑾  沈雪勇  王丽祯  赵玲  吴凡  张海蒙
作者单位：任秀梅 (上海中医药大学针灸推拿学院,上海201203,中国) ; 曹锦瑾 (南通大学附属医院针灸科,江苏南通226001) ; 沈雪勇 (上海中医药大学针灸推拿学院,上海201203,中国) ; 王丽祯 (上海中医药大学针灸推拿学院,上海201203,中国) ; 赵玲 (上海市针灸经络研究中心) ; 吴凡 (上海中医药大学针灸推拿学院,上海201203,中国) ; 张海蒙 (上海中医药大学针灸推拿学院,上海201203,中国) ;
基金项目：National,973,Project,The,Leading,Academic,Discipline,Project,of,State,Administration,of,TCM,and,the,City,of,Shanghai:,The,Scientific,and,Technological,Brainstorm,Project,of,Shanghai:
摘    要：目的:观察艾灸对膝骨性关节炎患者疼痛、僵硬、功能障碍等症状的疗效,评价艾灸疗法的有效性和安全性。方法:59例膝骨性关节炎患者随机分为艾灸组(31例)和安慰艾灸组(28例),分别将治疗艾炷和安慰艾炷粘贴在内膝眼、犊鼻、阿是穴处给予艾灸治疗,每次每穴3壮,隔日1次,每周3次,连续治疗6周,统计治疗3周、6周时的疗效,并于治疗结束后6周对患者进行随访。采用骨关节炎调查量表(WOMAC)、46 m最快步行时间评价关节功能恢复情况,使用UT-325数字温测仪记录膝关节疼痛最明显的治疗点艾灸前后温度变化。结果:艾灸组治疗3周、6周及随访时WOMAC量表各项评分均明显降低(P<0.05,P<0.01,P<0.001);安慰艾灸组随访时僵硬评分较治疗前降低(P<0.05);治疗6周及随访时,艾灸组较安慰艾灸组疼痛、僵硬、功能障碍评分下降更明显(P<0.01,P<0.05)。艾灸组治疗6周后46 m最快步行时间较治疗前明显缩短(P<0.01),而安慰艾灸组治疗后改善不明显(P>0.05),组间比较差异无统计学意义(P>0.05)。艾灸组艾灸后治疗点温度为(49.81±3.10)℃,安慰艾灸组为(40.98±1.67)℃,两组均较治疗前局部皮肤温度明显升高(P<0.001,P<0.01),艾灸组温度升高更明显(P<0.001)。结论:艾灸可明显改善膝骨性关节炎患者疼痛、僵硬、功能障碍等临床症状,是一种安全、有效的治疗方法。
关 键 词：骨性关节炎  膝  艾灸  随机对照试验

Preliminary clinical randomized controlled trial on knee osteoarthritis treated with moxibustion
Xiu-mei REN,Jin-jin CAO,Xue-yong SHEN,Li-zhen WANG,Ling ZHAO,Fan WU,Hai-meng ZHANG.Preliminary clinical randomized controlled trial on knee osteoarthritis treated with moxibustion[J].World Journal of Acupuncture-Moxibustion,2012,22(2):28-33.
Authors:Xiu-mei REN  Jin-jin CAO  Xue-yong SHEN  Li-zhen WANG  Ling ZHAO  Fan WU  Hai-meng ZHANG
Institution:1. Acupuncture-Moxibustion and Massage College, Shanghai University of TCM, Shanghai 201203, China; 2. Acupuncture and Moxibustion Department, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China; 3. Shanghai Research Center of Acupuncture and Meridians LIU Zhao
Abstract:ObjectiveTo observe the therapeutic effect of moxibustion on pain, stiffness and physical dysfunction caused by knee osteoarthritis (KOA), and make an assessment on the effectiveness and safety of this therapy.MethodsFifty-nine cases of KOA were randomly divided into a moxibustion group (31 cases) and a sham-moxibustion group (28 cases). The treatment of moxibustion was given at Nèixīy?n (
></figure> EX-LE 4), Dúbi (<figure class=></figure> ST 35) and <em>Ashi</em> points with real moxa cone in the moxibustion group and sham moxa cone in the sham-moxibustion group, 3 cones on each point per time, once every two days, 3 times per week for consecutively 6 weeks. The results were recorded in week 3 and 6 of the treatment, and the follow-up visit was performed 6 weeks after the end of treatment. The Western Ontario and Mcmaster Universities Osteoarthritis Index (WOMAC) and the shortest walking time of 46 m were adopted to evaluate the recovery situation of joint function. The UT-325 digital thermal detector was put to use to record the temperature change in the most obvious painful points of knee joint before and after the moxibustion.<b>Results</b>All the scores of WOMAC in the moxibustion group were apparently decreased in week 3 and 6 of the treatment as well as the follow-up visit, separately (<em>P</em><0.05, <em>P</em><0.01, <em>P</em><0.001). The stiffness score of follow-up visit in the sham-moxibustion group, compared before the treatment, was lowered (<em>P</em><0.05). The scores of pain, stiffness and physical function in the moxibustion group had a greater decrease than those in the sham-moxibustion group in week 6 of treatment and the follow-up visit (<em>P</em><0.01, <em>P</em><0.05). The shortest walking time of 46 m in the moxibustion group after 6 weeks of the treatment was apparently reduced as compared with that before treatment (<em>P</em><0.01), but there was no apparent improvement in the sham-moxibustion group (<em>P</em>>0.05), and the between-group difference was not significant statistically (<em>P</em>>0.05). The temperature of treatment point after the moxibustion was (49.81±3.10) °C in the moxibustion group and (40.98±1.67) °C in the sham-moxibustion group, which was both increased apparently as compared with that before the treatment (<em>P</em><0.001, <em>P</em><0.01), and more obviously in the moxibustion group (<em>P</em><0.001).<b>Conclusion</b>The moxibustion, which can obviously improve the clinical symptoms of the patients with KOA, such as pain, stiffness and physical dysfunction, is safe and effective.</td> </tr> <tr> <td align=
Keywords:osteoarthritis  knee  moxibustion  randomized controlled trial (RCT)
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