Epstein-Barr virus-specific cytotoxic T cell responses in rheumatoid arthritis patients |
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Authors: | J. S. H. Gaston A. B. Rickinson M. A. Epstein |
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Affiliation: | (1) Department of Pathology, University of Bristol, The Medical School, University Walk, BS8 1TD Bristol, UK |
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Abstract: | Summary The level of Epstein-Barr (EB) virus-specific cytotoxic T cell responsiveness was measured in 21 patients with active, progressive rheumatoid arthritis (RA). A significant number (8 out of 20) of EB virus sero-positive patients showed a markedly impaired responsiveness when compared with a control group of healthy individuals. Serological responses of the RA patients to EB virus antigens were not significantly different from the control group. The defect in EB virus-specific cellular immunity shown by these results is of interest in the light of previous evidence of an alteration in the virus-host balance in RA patients. |
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Keywords: | Epstein-Barr virus Cytotoxic T cell Rheumatoid arthritis Cellular immunity |
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