Outcomes of donation after circulatory death kidneys undergoing hypothermic machine perfusion following static cold storage: A UK population‐based cohort study |
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Authors: | Kamlesh Patel Jay Nath James Hodson Nicholas Inston Andrew Ready |
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Institution: | 1. Department of Renal Surgery, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK;2. Institute of Metabolism and Systems Research, School of Medical and Dental Science, University of Birmingham, Birmingham, UK;3. Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK |
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Abstract: | Evidence is currently lacking regarding the outcomes of kidneys undergoing hypothermic machine perfusion (HMP) in patients in the United Kingdom. Using the National Health Service Blood and Transplant database, the authors compared outcomes for recipients of single‐organ donation after circulatory death (DCD) kidneys preserved with HMP with those preserved using only static cold storage (SCS). Between 2007 and 2015, HMP was used in 19.1% (864/4,529) of kidneys. Rates of delayed graft function (DGF) were significantly lower in organs preserved with HMP than for organs preserved with SCS (34.2% vs 42.0%, P < .001), despite a slightly longer cold ischemic time (median: 14.8 vs 14.1 hours, P < .001). Multivariable analysis found the effect of preservation modality to remain significant, with HMP organs having a significantly lower rate of DGF (odds ratio 0.65, 95% confidence interval 0.53‐0.80, P < .001) and significantly shorter times to DGF resolution (average: 6.1 vs 7.4 days, P = .003) than SCS organs. The patient (P = .313) and graft (P = .263) survival rates were similar in the 2 preservation groups. HMP was associated with a marginal functional benefit in 1‐year creatinine values (P = .044), with adjusted averages of 1.36 mg/dL (HMP) versus 1.40 mg/dL (SCS). This study supports the use of HMP and aids decision‐making over its instigation, which may improve short‐term patient outcomes. |
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Keywords: | clinical research/practice kidney transplantation/nephrology organ perfusion and preservation organ procurement and allocation registry/registry analysis |
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