慢性胃炎脾胃湿热证的免疫组织化学研究

为探讨慢性胃炎脾胃气虚证患者胃粘膜组织和外周血的免疫反应状态及其发生原因，用免疫组织化学等方法，观察该证的胃粘膜炎症类型和与幽门螺杆菌（HP）感染的关系。结果发现，慢性胃炎脾胃湿热证患者淋巴细胞亚群在胃粘膜和外周血的反应明显增强；胃粘膜树突状细胞（DC）明显增加；体液免疫的IgG，胃粘膜和外周血反应均增加，而IgA、IgM仅胃粘膜反应显著增强，免疫复合物（CIC）也明显增高。其中HP阳性者T淋巴细胞亚群仅胃粘膜明显增加，DC亦明显增强；体液免疫的IgG，胃粘膜和外周血均显著增强，IgA、IgM仅胃粘膜显著增强，CIC亦明显升高；HP阳性者胃粘膜的IgG、IgA以及CIC也增强。表明慢性胃炎脾胃气虚证胃粘膜较外周血免疫反应更敏感，HP感染是引起胃粘膜免疫反应的主要原因。

Immunohistochemical Study on Chronic Gastritis Patients with Dampness and Heat in Spleen and Stomach

In order to research the immune reactive state and causes of chronic gastritispatients with dampness and heat in spleen and stomach(DHSS) the relationship between gastricmucosa inflammatory types and HP infection was observed by using immunohistochemicalmethod. The results showed that the T lymphocyte subpopulation (TLS) humoral immune IgGwere obviously increased in gastric mucosa (GM) and peripheral blood (PB), while the IgA,IgM,dendritic cell (DC) of GM, immunocomplex (CIC) were also markedly rise only in GM.Among these cases of HP infection patients TI-S was enhanced in GM and PB. The other indexeswere significantly increased only in GM. IgG,IgA,CIC in GM of HP negative patients were alsoenhanced. It suggested the chronic gastritis patients with DHSS immunocreative in GM was moresensitive than that in the PB. HP infection was a chief cause for immune reaction of GM.