Effects of piperine on testis of albino rats. |
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Authors: | T Malini R R Manimaran J Arunakaran M M Aruldhas P Govindarajulu |
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Affiliation: | Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, Taramani, Madras, India. |
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Abstract: | Piperine was administered to mature male albino rats at doses of 5 and 10 mg/kg body weight, p.o., respectively, for 30 days. Only a 10 mg dose of piperine treatment caused a significant reduction in the weights of testis and accessory sex organs. Histological studies revealed that piperine at a 5 mg dose caused partial degeneration of germ cell types, whereas at a 10 mg dose, it caused severe damage to the seminiferous tubule, decrease in seminiferous tubular and Leydig cell nuclear diameter and desquamation of spermatocytes and spermatids. Correlated to the structural changes, a fall in caput and cauda epididymal sperm concentrations was also evident. A 10 mg dose of piperine also caused a marked increase in serum gonadotropins and a decrease in intratesticular testosterone concentration, despite normal serum testosterone titres. |
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