白介素-8、白介素-15在结肠癌患者结肠黏膜的表达及意义

目的:研究结肠癌患者结肠黏膜中白介素-8(IL-8)、白介素-15(IL-15)的表达并探讨其临床应用价值．方法:采用免疫组化法检测结肠癌患者结肠黏膜中IL-8,IL-15的表达情况．结果:IL-8染色阳性44例,占66．7％．IL-15染色阳性40例,占60．6％．IL-8和IL-15表达水平与结肠癌临床分期(IL-8:r=0．437,P=0．006; IL-15:r=0．317,P=0．014)、浸润深度(IL-8: r=0．332,P=0．003;IL-15:r=0．312,P= 0．015)、淋巴结转移(IL-8:r=0．316,P=0．042; IL-15:r=0．236,P=0．017)、病理分级(IL-8:r =0．826,P=0．0001;IL-15:r=0．368,P=0．001)均呈显著正相关．结论:检测IL-8,IL-15的表达可做为判断结肠癌恶性程度有价值的指标．

Expression and significances of interleukin-8 and interleukin-15 in colonic mucosa of colon cancer patients

AIM: To investigate the expression of interleukin-8 (IL-8) and IL-15 in colonic mucosa from colon cancer patients and study their relationships with colon cancer. METHODS: Immunohistochemical technique was used to detect the expression of IL-8 and IL-15 in 66 patients with colon cancer. RESULTS: The positive rates of IL-8 and IL-15 were 66.7% (44/66) and 60.6% (40/66), respectively. Significant correlations existed between expression of IL-8, IL-15 and the following factors: clinical stages (IL-8: r = 0.437, P = 0.006; IL-15: r = 0.317, P = 0.014), invasive depth (IL-8: r = 0.332, P = 0.003; IL-15: r = 0.312, P = 0.015), regional lymph node metastasis (IL-8: r = 0.316, P = 0.042; IL-15: r = 0.236, P = 0.017), histologic grades (IL-8: r = 0.826, P = 0.0001; IL-15: r = 0.368, P = 0.001). CONCLUSION: Detection of IL-8 and IL-15 ex pression is helpful in assessing the malignant degrees of colon cancer.