Requirement of extracellular Ca2+ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices |
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| Authors: | Y Izumi K Ito H Miyakawa H Kato |
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| Affiliation: | 1. Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China;2. Department of Neurology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China;3. Department of Biochemistry and Molecular Biology, College of Life Science, Nankai University, Tianjin 300071, China;1. King''s College London, London, United Kingdom;4. University of Siena, Siena, Italy;5. University of Oxford, Oxford, United Kingdom |
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| Abstract: | Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). Replacement of a standard solution containing 2.0 mM Ca2+ with one containing 1.0 mM Ca2+ for 5 min, either immediately after or during tetanus, significantly inhibited the induction of LTP. Furthermore, similar results were obtained when Verapamil or Loperamide, presumable Ca2+ antagonists, was applied immediately after tetanus. From these results, it was concluded that the induction of LTP requires extracellular Ca2+ after as well as during tetanus. |
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