水杨酸联合米诺环素在痤疮治疗中的应用价值

探讨水杨酸联合米诺环素治疗痤疮的价值。方法 选取赤水市市中街道社区卫生服务中心2020年7月-2022年7月收治的126例痤疮患者,采用随机数字表法分为观察组和对照组,各63例。对照组采用米诺环素治疗,观察组采用水杨酸联合米诺环素治疗,比较两组临床疗效、皮肤相关指标、GAGS评分、生活质量以及不良反应情况。结果 观察组治疗总有效率为96.83%,高于对照组的76.19%,差异有统计学意义（P ＜0.05）;观察组红斑指数、CEA分数及皮损数均低于对照组,差异有统计学意义（P ＜0.05）;观察组治疗2、4、8周后GAGS评分均低于对照组,差异有统计学意义（P ＜0.05）;观察组治疗后自我感知、社会功能、情感功能评分均高于对照组,差异有统计学意义（P＜0.05）;观察组不良反应发生率与对照组比较,差异无统计学意义（P ＞0.05）。结论 水杨酸联合米诺环素治疗痤疮疗效理想且安全性高,可有效改善临床症状,进而提升其生活质量。

Application Value of Salicylic Acid Combined with Minocycline in the Treatment of Acne

To explore the value of salicylic acid combined with minocycline in the treatment of acne. Methods Atotal of 126 acne patients admitted to Shizhong Street Community Health Service Center of Chishui from July 2020 to July 2022were selected and divided into observation group and control group by random number table method, with 63 patients in eachgroup. The control group was treated with minocycline, and the observation group was treated with salicylic acid combined withminocycline. The clinical efficacy, skin-related indicators, GAGS score, quality of life and adverse reactions were comparedbetween the two groups. Results The total effective rate of treatment in the observation group was 96.83%, which was higher than76.19% in the control group, and the difference was statistically significant (P <0.05). The erythema index, CEA score and numberof skin lesions in the observation group were lower than those in the control group, and the differences were statistically significant(P <0.05). After 2,4 and 8 weeks of treatment, the GAGS score of the observation group was lower than that of the control group,and the difference was statistically significant (P <0.05). After treatment, the scores of self-perception, social function and emotionalfunction in the observation group were higher than those in the control group, the differences were statistically significant (P <0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P >0.05). Conclusion Salicylic acid combined with minocycline is effective and safe in the treatment of acne, which can effectivelyimprove the clinical symptoms and the quality of life.