Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2 |
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| Authors: | Christina Chuong Christine M. DuChane Emily M. Webb Pallavi Rai Jeffrey M. Marano Chad M. Bernier Joseph S. Merola James Weger-Lucarelli |
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| Affiliation: | 1.Department of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA; (C.C.); (P.R.);2.Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA; (C.M.D.); (C.M.B.);3.Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA;4.Department of Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061, USA; |
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| Abstract: | SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl2 (complex 2) and Cp*Rh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity. |
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| Keywords: | SARS-CoV-2 COVID-19 organometallics metallodrugs antiviral virucidal |
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