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造血干细胞动员剂硫酸葡聚糖的临床前及人体试用研究
引用本文:马恩普 刘景汉. 造血干细胞动员剂硫酸葡聚糖的临床前及人体试用研究[J]. 军事医学科学院院刊, 1992, 16(2): 81-85
作者姓名:马恩普 刘景汉
作者单位:北京放射医学研究所,北京放射医学研究所,北京放射医学研究所,北京放射医学研究所,北京放射医学研究所,中国长城医院,北京放射医学研究所
摘    要:为了阐明临床应用造血干细胞动员剂硫酸葡聚糖(DS)的可能性,用不同动物进行了动员效果、LD_(50)过敏实验和正常人体试用研究。结果表明,给狗静脉注射分子量为10kDa的DS后,血中MNC和CFU-GM呈时相性变化,1h开始增加,5h达到高峰值;LD_(50)为1128.6mg/kg(雄性小鼠)和1369.4mg/kg(雌性小鼠),两者之间无显著差异;分子量为10kDa的DS过敏反应为阴性结果,15kDa的DS为阳性结果;34例正常人体试用,DS可使血中CFU-GM、BFU-E和CFU-GEMM,分别增加到给药前的8倍、10.5倍和12倍,有效、安全剂量约为15~20mg/kg。分子量为10kDa的DS人体试用研究属国内外首次报道。

关 键 词:造血干细胞 动员剂 硫酸葡聚糖

EXPERIMENTAL STUDY AND NORMAL INDIVIDUAL TRIAL USE OF HEMOPOIETIC STEM CELL MOBILIZER DS
Ma Enpu Guo Shuhua Wei Handong Liu An Ding Linmao Liu Jinghan Jiang Youmin. EXPERIMENTAL STUDY AND NORMAL INDIVIDUAL TRIAL USE OF HEMOPOIETIC STEM CELL MOBILIZER DS[J]. Bulletin of the Academy of Military Medical Sciences, 1992, 16(2): 81-85
Authors:Ma Enpu Guo Shuhua Wei Handong Liu An Ding Linmao Liu Jinghan Jiang Youmin
Affiliation:Beijing Institute of Radiation Medicine
Abstract:In order to determine the possibility of the clinical application of the mobilizer DS, studies on its mobilizing effect, LD_(50), anaphylactic reaction and normal individual trial use were carried out. The results showed that the numbers of MNC and CFU-GM in peripheral blood began to increase and reached peak values 5 hours after intravenous injection of DS with molecular weight of 10kDa; LD_(50) of DS in male and female mice were 1128.6 mg/kg and 1369.4 mg/kg respectively. The difference is insignificant. DS with MW of 10kDa had a negative anaphylactic reaction while that of 15kDa gave a positive one. In the trial use of DS, the numbers of CFU-GM, BFU-E and CFU-GEMM in peripheral blood increased by 8, 10.5 and 12 fold respectively, in 34 volunteers. The safe and effective dose of DS was about 15-20 mg/kg. The normal individual trial use of DS with MW of 10kDa has not been reported yet in literature.
Keywords:hemopoietic stem cell mobilizer  dextran sulfate  toxicity and side effects  normal individual trial
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