家兔急性实验时糖尿现象的激素机制

实验在急性实验条件下的10只兔身上进行,同时测定血清胰岛素、皮质醇和尿中VMA在手术后的变化;並对四只犬进行同样的观察。结果:手术后,家兔尿中的VMA含量逐渐升高,由9.0±3.02μg/ml升至23.4±6.78μg/ml,p<0.01;血清中的胰岛素含量则逐渐降低,由60.5±14.52μu/ml降为42.4±14.09μu/ml,P<0.05。犬的上述激素的含量变化与兔相反。兔和犬血清中皮质醇平均含量均有升高的趋势,但无统计学意义。表明兔在急性实验时儿茶酚胺的分泌增加,胰岛素的分泌减少,是导致其血糖浓度进行性升高,产生糖尿现象的激素机制。

THE HORMONE MECHANISM OF GLYCOSURIA PHENOMENON AT ACUTE EXPERIMENT IN RABBITS

Under the condition of acute experiment the concentration of insulin and cortisor in serum and VMA in urine in ten rabbits were determined before and/or after experimental operation with an interval of 60 minutes, The same observations were done on four dogs. The content of VMA in urine of rabbits (detected at 30, 90 and 150minutes after the beginning of operation) was elevated gradually, averaging from 9.0±3.02μg/ml to 17.5±3.51μg/ml (p<0.01) and 23.4 ±6.78μg/ml (p<0.01), while the content of insulin in serum was reduced from 60.5±14.52μu/ml to 49.6±14.47μu/ml (p>0.05) and 42.4±14.09μu/ml (p<0.05). The change of above hormones in dogs was opposite to that in rabbits, the content of VMA in dogs was reduced and content of insulin was elevated gradually. The average content of cortisol in serum both in rabbits and dogs had tendency to elevate but had no statistic significance. It is indicated that the of increase of excretion of catecholamine and the decrease of excretion of insulin at acute experiment in rabbits result in the elevation of blood sugar concentration progressively and are the hormone mechanism of production phenomenon of glycosuria.