| p53 p16 pRb的表达与尖锐湿疣癌变的关系 |
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| 引用本文： | 陈丽,褚昕. p53 p16 pRb的表达与尖锐湿疣癌变的关系[J]. 中国艾滋病性病, 2010, 0(2) |
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| 作者姓名： | 陈丽 褚昕 |
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| 作者单位： | 南昌大学第一附属医院皮肤科; |
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| 基金项目： | 江西省卫生厅课题(20041048)~~ |
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| 摘 要： | 目的通过观察外阴尖锐湿疣和外生殖器鳞状细胞癌人乳头瘤病毒(HPV)16/18型的感染情况,以及抑癌基因或癌蛋白53(p53)、细胞周期蛋白酶抑制物(p16)基因、视网膜母细胞瘤(pRb)蛋白的表达情况,进一步分析外阴尖锐湿疣和鳞状细胞癌之间的关系。方法取外阴尖锐湿疣50例,外生殖器鳞状细胞癌20例,全部标本用HPV16/l8基因探针行分子原位杂交,免疫组织化学染色,并测定p53、p16、pRb的阳性指数和平均吸光度。结果(1)HPVl6/l8阳性组的p16、pRb表达率与鳞癌组差异无统计学意义(P0.05);(2)HPVl6/l8阳性组p53、p16、pRb的阳性指数、吸光度,与HPVl6/l8阴性组和鳞癌组的差异均有统计学意义(均P0.01)。结论HPVl6/l8型感染与癌变有关,检测p53、p16、pRb的表达有助于预测癌变风险。
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| 关 键 词： | p53 p16 pRb 尖锐湿疣 癌变 人乳头瘤病毒 |
Expressions of p53,p16 and pRb and its relationship with cancerization of condyloma acuminatum |
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| CHEN Li,ZHU Xin.. Expressions of p53,p16 and pRb and its relationship with cancerization of condyloma acuminatum[J]. Chinese JOurnal of Aids & STD, 2010, 0(2) |
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| Authors: | CHEN Li ZHU Xin. |
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| Affiliation: | CHEN Li,ZHU Xin. (Department of Dermatology,First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi 330006,China) |
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| Abstract: | Objective To investigate the prevalence of HPV16/18 infection in condyloma acuminatum (CA) in vulva and in genital squamous cell carcinoma, and to explore the relationship between expressions of p53, p16 and pRb and the cancerization of condyloma acuminatum. Methods A total of 70 skin biopsy specimens including 50 CA samples and 20 carcinoma samples were collected. Hybridization in situ was used to detect HPV16/18 infection. Immunohistochemisty was used to identify the expressions of p53, p16 and pRb. Resul... |
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| Keywords: | p53 p16 pRb Condyloma acuminatum Cancerization |
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