| 经维甲酸处理的瘤细胞作为“瘤苗”的免疫治疗实验 |
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| 引用本文： | 于晓妉,赵雪梅,高进. 经维甲酸处理的瘤细胞作为“瘤苗”的免疫治疗实验[J]. 中华微生物学和免疫学杂志, 1995, 0(4) |
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| 作者姓名： | 于晓妉 赵雪梅 高进 |
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| 作者单位： | 中国医学科学院基础医学研究所，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所 100005 北京，100005 北京，100005 北京 |
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| 摘 要： | 为观察维甲酸对体外培养的肿瘤细胞免疫原性的影响,本实验将经维甲酸处理的小鼠前胃癌(MFC)细胞作为活瘤苗,进行了免疫接种及免疫治疗的实验观察。结果表明免疫接种小鼠可完全排斥再次接种未经药物处理瘤细胞的生长,同时伴有体内细胞免疫反应增强。将该瘤苗用于荷瘤小鼠的免疫治疗,可使肿瘤生长速度减慢,荷瘤生存期明显延长,提示维甲酸可通过改变肿瘤细胞的免疫原性介导机体抗瘤反应。
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| 关 键 词： | 维甲酸 肿瘤疫苗 免疫治疗 |
RETINOIC ACID TREATED TUMOR CELLS AS A TUMOR VACCINE USED FOR VACCINATION AND IMMUNOTHERAPY |
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| Yu Xiaodan,Zhao Xuemei,Gao Jin Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,Beijing. RETINOIC ACID TREATED TUMOR CELLS AS A TUMOR VACCINE USED FOR VACCINATION AND IMMUNOTHERAPY[J]. Chinese Journal of Microbiology and Immunology, 1995, 0(4) |
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| Authors: | Yu Xiaodan Zhao Xuemei Gao Jin Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing |
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| Affiliation: | Yu Xiaodan,Zhao Xuemei,Gao Jin Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,Beijing 100005 |
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| Abstract: | To investigate the effect of retinoic acid (RA) on immunogenicity of cultured tumor cells,the cultured mouse forestomach carcinoma (MFC) cells treaed by RA were used as an active vaccine to immunize naive or tumorbearing syngeneic mice. The results showed that the naive mice immunized with treated MFC cells,when challenged by se injection of untreated MFC cells,were tumor free and accompanied by increased cell-mediated immunity. Vaccine treatment in the tumorbearing mice could also induce antitumor immunity significantly as demonstrated by diminished tumor growth and increased duration of survival after challenge. These data suggest that RA can induce antitumor immunity by modulating the immunogenicity of tceated-cells. |
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| Keywords: | Retinoic acid Tumor vaccine Immunotherapy |
| 本文献已被 CNKI 等数据库收录！ |
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