亚冬眠疗法对急性心肌梗死患者心肌保护作用的研究

目的探讨亚冬眠疗法对急性心肌梗死患者的心肌保护作用并推测其可能机制。方法入选患者随机分为干预组和对照组,在常规治疗的基础上,干预组予冬眠合剂持续泵入,观察其体温、血压、心率、呼吸频率变化,测定血浆去甲肾上腺素(NE)(、血清钾离子(K )和镁离子(Mg2 )含量,记录住院天数和心律失常、心力衰竭、死亡例数。结果干预组体温、血压、血浆NE含量和住院天数均明显低于对照组(P<0.01),血清K 、Mg2 含量高于对照组(P<0.05),心律失常和心力衰竭例数较对照组减少(P<0.05)。结论亚冬眠疗法可降低急性心肌梗死患者体温和血压,减少应激性NE释放,有效维持心功能,减少电解质紊乱、心律失常等恶性后续反应,缩短了住院时间。

The protective effect of artificial hibernation therapy on patients with acute myocardial infarction

Objective The aim was to study the protective effect of artificial hibernation therapy on patients with acute myocardial infarction and to investigate the mechanism. Methods The selected patients were divided into two groups randomly. The patients in intervening group were treated with cocktail besides conventional therapy. The change of temperature, blood pressure, heart rate and respiratory rate was observed. The level of NE in plasma, and the level of K and Mg2 in serum were determined. The hospital day and the number of cases with arrhythmia, heart failure and death were recorded. Results The temperature, blood pressure, the level of NE in plasma and the hospital day was significantly lower than that of the contrast group(P<0.01). The level of K and Mg2 in serum was higher than that of the contrast group(P<0.05).The number of cases with arrhythmia and heart failure was fewer than that of the contrast group(P<0.05). Conclusion The results suggest artificial hibernation therapy can depress the temperature and blood pressure of patients, reduce the release of NE, maintain heart function, interrupt some serious complication such as electrolyte disturbance, arrhythmia and so on, and shorten the hospital day.