| 5-氟尿嘧啶代谢酶在胃癌中的表达及预后价值 |
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| 引用本文： | 马韬,计骏,张俊,于颖彦,刘炳亚,叶正宝,朱正纲.5-氟尿嘧啶代谢酶在胃癌中的表达及预后价值[J].内科理论与实践,2009,4(1):37-40. |
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| 作者姓名： | 马韬 计骏 张俊 于颖彦 刘炳亚 叶正宝 朱正纲 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院胃肠肿瘤专科;上海交通大学医学院附属瑞金医院外科上海市消化外科研究所; |
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| 摘 要： | 目的:探讨二氢嘧啶脱氢酶(dihydropyrimidine dehydrogenase,DPD)、胸苷酸合成酶(thymidylate synthase,TS)和胸苷磷酸化酶(thymidine phosphorylase,TP)在胃癌中的表达及预后价值。方法:42例胃癌患者于根治术后分别施以5-氟尿嘧啶(5-FU)为主的辅助化疗,并通过免疫组织化学检测DPD、TS和TP的表达,比较上述代谢酶表达与临床病理因素和预后之间的关系。结果:胃癌组织中DPD在肠型中的表达率显著高于弥漫型(65%比25%,P=0.025),TS和TP倾向高表达于分期较晚的胃癌患者中(P0.05)。结论:在接受5-FU为主的辅助化疗胃癌患者中,DPD表达有可能成为重要的预后指标;而TS和TP表达则与肿瘤进展及临床分期密切相关。
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| 关 键 词： | 胃癌 二氢嘧啶脱氢酶 胸苷酸合成酶 胸苷磷酸化酶 5-氟尿嘧啶 预后 |
Expressions and prognostic values of 5-fluorouracil metabolic enzymes in gastric carcinoma |
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| MA Tao,JI Jun,ZHANG Jun,YU Ying-yan,LIU Bing-ya,YE Zheng-bao,ZHU Zheng-gang.Expressions and prognostic values of 5-fluorouracil metabolic enzymes in gastric carcinoma[J].Joournal of Internal Medicine Concepts& Practice,2009,4(1):37-40. |
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| Authors: | MA Tao JI Jun ZHANG Jun YU Ying-yan LIU Bing-ya YE Zheng-bao ZHU Zheng-gang |
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| Institution: | MA Tao~a,b,JI Jun~b,ZHANG Jun~a,YU Ying-yan~b,LIU Bing-ya~b,YE Zheng-bao~a,ZHU Zheng-gang~a,b.a.Division of Gastrointestinal Cancer,b.Department of Surgery,Ruijin Hospital,Shanghai Jiaotong University,School of Medicine,Shanghai 200025,China |
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| Abstract: | Objective To investigate the expressions and prognostic values of dihydropyrimidine dehydrogenase(DPD),thymidylate synthase(TS) and thymidine phosphorylase(TP) in gastric carcinoma,and to analyze the correlations between the expressions of these enzymes and the clinicopathological features and prognosis.Methods Expressions of DPD,TS and TP were determined by immunohistochemistry in 42 gastric carcinoma patients who had received 5-fluorouracil(5-FU)-based adjuvant chemotherapy after curative resection,and th... |
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| Keywords: | Gastric carcinoma Dihydropyrimidine dehydrogenase Thymidylate synthase Thymidine phosphorylase 5-fluorouracil Prognosis |
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