| 吲哚胺2,3双加氧酶的表达及其在肿瘤免疫耐受中的作用 |
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| 引用本文： | 杨洁,王琦. 吲哚胺2,3双加氧酶的表达及其在肿瘤免疫耐受中的作用[J]. 医学综述, 2008, 14(1): 75-77 |
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| 作者姓名： | 杨洁 王琦 |
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| 作者单位： | 山西医科大学附属第二医院消化内科,太原,030001 |
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| 摘 要： | 吲哚胺2,3双加氧酶(IDO)是色氨酸沿犬尿酸途径分解代谢的限速酶,在体内的分布比较广泛。脂多糖、细胞因子如γ-干扰素等多种物质可以通过不同的机制调节IDO的表达。在某些肿瘤类型中,IDO可以诱导机体产生针对肿瘤的免疫耐受。对IDO的这种免疫调节机制的深入研究将在肿瘤治疗方面具有重大的意义。
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| 关 键 词： | 肿瘤 吲哚胺2,3双加氧酶 免疫调节 |
| 文章编号： | 1006-2084（2008）01-0075-03 |
| 收稿时间： | 2007-01-27 |
| 修稿时间： | 2007-06-06 |
Expression of Indoleamine 2,3-dioxygenase and the Role in Tumor Immunological Tolerance |
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| YANG Jie,WANG Qi. Expression of Indoleamine 2,3-dioxygenase and the Role in Tumor Immunological Tolerance[J]. Medical Recapitulate, 2008, 14(1): 75-77 |
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| Authors: | YANG Jie WANG Qi |
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| Affiliation: | YANGJie,WANG Qi.(Department of Digestive Diseases, Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China) |
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| Abstract: | Indoleamine 2,3-dioxygenase（IDO） is the rate-limiting enzyme in the catabolism of trypto-phan along the kynurenine pathway, which is widely distributed in the body. Lipopolysaccharide （LPS） and cytokines such as IFN-γ and so on can regulate the expression of IDO via different regulating mechanisms. In some kinds of tumors, IDO can induce immunological tolerance to tumor. Further research on this immunological regulatory mechanism will be significant for tumor immunotherapy. |
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| Keywords: | Tumor Indoleamine 2 3-dioxygense Immune regulation |
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