基底细胞样型乳腺癌病理诊断及治疗预后分析

目的探讨基底细胞样型乳腺癌（BLBC）的临床病理特征、免疫表型特点及治疗预后。方法收集乳腺浸润性导管癌患者101例,筛选出BLBC15例,总结其临床资料、组织病理学特征,并进行免疫组化SP法染色。选用的抗体包括CK5／6、EGFR、vimentin、ER、C—erbB-2等。结果15例BLBC病理组织形态学表现为典型的BLBC病理特征。15例乳腺BLBC的免疫表型均为ER、c-erbB-2阴性,而CK5／6、EGFR及vimentin阳性。BLBC与其他浸润性导管癌相比,发病年龄轻,肿瘤大,易出现淋巴结转移。术后易复发转移。结论BLBC是一种特殊表型的乳腺癌,具有独特的免疫组化特征、组织形态学特点及生物学特性。预后较差．应作为一种独立的乳腺癌亚型加以重视。

Analysis for the clinical pathological diagnose and prognosis of basal-like breast carcinoma

Objective To investigate the clinical pathological features,immunophenotype and prognosis of basal-like breast carcinoma（BLBC）. Methods The 15 cases of BLBC were selected from 101 eases of breast invasive ductal carcinoma, and the patients＇ clinical data and tissue pathological features of basal-like breast carcinoma were analyzed, and the samples were stained by immunohistochemical SP method with the antibodies including cytokeratin 5/6, EGFR, vimentin, estrogen receptor, c-erbB-2, etc. Results The 15 cases of BLBC showed typical pathological characteristics of BLBC. The immunophenotypes of the 15 cases of BLBC were negative for ER,c-erbB-2 and positive for cytokeratin 5/6, vimentin and EGFR. As compared with other breast invasive ductal carcinomas, BLBC showed the characteristics including younger age at onset, larger size of tumor, more lymphatic metastasis and higher recurrence rate after operation. Conclusion BLBC is a special phenotypie breast carcinoma with unique immunohistoehemical characteristics, histomorphological features and poor prognosis, so we have to pay much attention to it as an independent subtype of breast carcinoma.