Evidence for a magnesium-insensitive membrane resistance increase during NMDA-induced depolarizations in rat neocortical neurons in vitro |
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| Authors: | B Sutor W Jordan W Zieglg?nsberger |
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| Institution: | 1. Department of Computer Science, Jordan University of Science and Technology, 22110, Jordan;2. Staffordshire University, Stafford, UK;3. Department of Computer Science, North Carolina State University, Raleigh, NC, USA;4. IBM Corporation, Center for Advanced Studies, Research Triangle Park, NC, USA;1. Farabi Eye Hospital BB, Eye Research Center, Tehran University of Medical Science, Tehran, Iran;2. Medical Physics and Biomedical Engineering Department, Recearch Center for Molecular and Cellular Imaging, Bio-Optical Imaging Group, School of Medicine, Tehran University of Medical Science, Tehran, Iran;3. Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA;4. Department of Ophthalmology, University of Colorado, School of Medicine, Aurora, Colorado, USA |
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| Abstract: | The responses of rat neocortical neurons in vitro to iontophoretically applied N-methyl-D-aspartate (NMDA) were investigated by means of intracellular recording in the presence and absence of extracellular magnesium ions (Mg2+). At Mg2+-concentrations of 1.3 mM the neurons responded with a depolarization accompanied by an increase in membrane resistance. Upon removal of Mg2+ the NMDA-induced depolarization was markedly potentiated. However, even in neurons recorded from slices which were incubated in a Mg2+-free solution for 3-7 h, the NMDA response was still associated with a resistance increase, suggesting that the voltage-dependence of the NMDA-activated conductance is not exclusively determined by Mg2+. |
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