| 内毒素性休克时血浆纤维连接蛋白与微血管通透性的关系 |
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| 引用本文： | 金惠铭,陈达信,闫友珍.内毒素性休克时血浆纤维连接蛋白与微血管通透性的关系[J].复旦学报(医学版),1990(6). |
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| 作者姓名： | 金惠铭 陈达信 闫友珍 |
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| 作者单位： | 上海医科大学基础医学部病理生理学教研室
(金惠铭，陈达信)，上海医科大学基础医学部病理生理学教研室(闫友珍) |
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| 基金项目： | 卫生部科学基金(编号87Y073) |
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| 摘 要： | 用异硫氰酸荧光素右旋糖酐-150作示踪剂,观察内毒素性休克时兔和大鼠微血管通透性变化。结果发现,内毒素性休克兔微血管通透性随休克进展进行性升高,血浆纤维连接蛋白(Fn)含量随之下降,两者呈显著相关(P<0.05)。在内毒素性休克大鼠中补充纯化大鼠Fn后,血浆Fn恢复,在静脉补充后2h内,微血管通透性升高受明显抑制,但2h后作用消失。与对照组(补充缺乏大鼠Fn血浆的内毒素性休克大鼠)相比,治疗组(补充纯化大鼠Fn)内毒素性休克大鼠的存活时间并无明显延长。
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| 关 键 词： | 内毒素性休克 纤维连接蛋白 微血管通透性 异硫氰酸荧光素右旋糖酐 |
PLASMA FIBRONECTIN AND MICROVASCULAR PERMEABILITY IN ENDOTOXIC SHOCK RABBITS |
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| Jin Huiming,Chen Daxin,Yan Yonzhen.PLASMA FIBRONECTIN AND MICROVASCULAR PERMEABILITY IN ENDOTOXIC SHOCK RABBITS[J].Fudan University Journal of Medical Sciences,1990(6). |
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| Authors: | Jin Huiming Chen Daxin Yan Yonzhen |
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| Abstract: | With FD-150 as a tracer, miorovasoular permeability was observed in 13 endo-toxie shook rabbits. The results showed that miorovasoular permeability increased while the content of plasma fibronectin (Pn) declined progressively during endoto-xio shook. There was a marked ocrrelation (P<0.05) between them. After infusion of purified rat Fn the content of plasma Fn returned almost to normal in these shocked rats. The increased miorovascular permeability was inhibited within 2 hours, but disappeared thereafter. There was no significant difference in survival time between treated rats (infusion of purified Fn) and control rats (infusion of Fn-deficient plasma). The significance of these results was briefly discussed. |
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| Keywords: | endotoxic shock fibronectin microvascular permeability |
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