辛伐他汀在不稳定型心绞痛中的作用研究

目的　探讨辛伐他汀在不稳定型心绞痛 (UAP)中的临床疗效、降脂效果及对血小板活化功能的影响。方法　将75例UAP患者随机分为对照组和治疗组。对照组给予常规治疗 ,治疗组在常规治疗基础上加用辛伐他汀 ,治疗 4周后观察临床疗效及血脂、GMP - 1 4 0变化情况。结果　治疗组与对照组显效率、有效率、无效率比较差异有显著性 (P <0 .0 5) ;辛伐他汀治疗组治疗后TC、TG、LDL -C、GMP - 1 4 0下降 (P <0 .0 1 ) ;HDL -C升高 (P <0 .0 1 )。结论　辛伐他汀能显著改善UAP的临床症状 ,降低TC、TG、LDL -C和升高HDL -C ,降低血小板活性 ,减少急性冠脉疾病的发生 ,降低猝死率

The effects of Simvastatin on unstable angina pectoris

Objective To study the clinical efficacy, decreasing blood-lipid and activating blood platelet function of Simvastatin on the treatment of unstable angina pectoris (UAP). Methods 75 cases with UAP were randomly allocated to a control group and a therapeutic group. The control group was given traditional treatment, and the therapeutic group received the traditional treatment plus Simvastatin. 4 weeks after treatment, all the clinical efficacy and the changes of blood lipid, GMP-140 were evaluated. Results In the control group and the therapeutic group, the comparison between the excellent curative rate, the good curative rate and the non-effectiveness rate had statistically significant differences (P<0.05). And in the therapeutic group, TC, TG, LDL-C and GMP-140 decreased after treatment (P<0.01); but HDL-C elevated (P<0.01). Conclusions Simvastatin could significantly improve the clinical symptom of UAP, decrease TC, TG, and LDL-C and elevate HDL-C, decrease the activity of blood platelet. It could also lower the incidence of acute coronary disease and the sudden death rate.