Antiarrhythmic properties of a new Suphan-based combined preparation and their possible mechanism of realisation |
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| Authors: | A I Khankoeva A S Dukhanin N B Leonidov P A Galenko-Yaroshevskii D S Galygo |
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| Institution: | (1) Department of Pharmacology, Kuban Medical Academy, Krasnodar;(2) Russian State Medical University, Moscow |
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| Abstract: | Considerable potentiation of antiarrhythmic and antifibrilation effects of two cardiotonic agents, Suphan and the Na-channel
blocker L1, was found in the model experimentsin vivo with early occlusion and reperfusion arrhythmias. Suphan in combination with L1 inhibited the rise of intracellular Ca2+ (by about 70%) in isolated cardiomyocytes incubated under hypoxic conditions.
Translated fromByulleten' Eksperimental'noi Biologii I Meditsiny, Vol. 125, No. 1, pp. 59–62, January, 1998 |
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| Keywords: | hypoxia sodium channel blockers antiarrhythmic drugs Ca-exchange cardiomyocytes |
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