| 阿魏酸钠微孔渗透泵片的体内药动学与生物利用度 |
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| 引用本文： | 何黎黎,张志荣,李立立,郑玲利. 阿魏酸钠微孔渗透泵片的体内药动学与生物利用度[J]. 中国药学杂志, 2007, 42(4): 295-297 |
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| 作者姓名： | 何黎黎 张志荣 李立立 郑玲利 |
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| 作者单位： | 1. 四川大学华西药学院,成都,610041;西南民族大学化学与环境保护工程学院,成都,610041
2. 四川大学华西药学院,成都,610041 |
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| 摘 要： | 目的研究阿魏酸钠微孔渗透泵片在Beagle犬体内的药动学。方法以阿魏酸钠普通片为对照,应用HPLC测定血药浓度。结果阿魏酸钠微孔渗透泵片和普通片的tmax分别为(4.833±0.725)和(1.000±0)h,t1/2分别为(12.892±2.879)和(5.824±1.659)h,ρmax分别为(2.227±0.583)和(12.942±1.568)mg·L-1。相对生物利用度为98.4%。结论阿魏酸钠微孔渗透泵片血药浓度平稳,可较长时间保持血药浓度。
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| 关 键 词： | 阿魏酸钠 微孔渗透泵片 高效液相色谱法 生物利用度 药动学 |
| 文章编号： | 1001-2494（2007）04-0295-03 |
| 收稿时间： | 2005-12-11; |
| 修稿时间： | 2005-12-11 |
Pharmacokinetics and Bioavailability of Sodium Ferulate Porosity Osmotic Pump Tablets in Beagle Dogs |
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| HE Li-li,ZHANG Zhi-rong,LI Li-li,ZHENG Ling-li. Pharmacokinetics and Bioavailability of Sodium Ferulate Porosity Osmotic Pump Tablets in Beagle Dogs[J]. Chinese Pharmaceutical Journal, 2007, 42(4): 295-297 |
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| Authors: | HE Li-li ZHANG Zhi-rong LI Li-li ZHENG Ling-li |
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| Affiliation: | 1. West China School of Pharmacy, Sichuan University, Chengdu 610041, China ;2. College of Chemisty and Envinonment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China |
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| Abstract: | OBJECTIVE To study the pharmacokinetics and bioavailability of Sodium Ferulate porosity osmotic pump tablets in beagle dogs.METHODS With sodium ferulate conventional tablets as reference,sodium ferulate concent-ration was determined by HPLC.RESULTS Main pharmacokinetic parameters were as follows: tmax(4.833±0.725) and(1.000±0)h,t1/2(12.892±2.879)and(5.824±1.659)h,ρmax(2.227±0.583) and(12.942±1.568)mg·L-1,for sodium ferulate porosity osmotic pump tablets and reference tablets,respectively.Relative bioavailability was 98.4%.CONCLUSION Plasma concentrations of sodium ferulate porosity osmotic pump tablets are constant and effective plasma drug concent-ration is kept for a long time. |
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| Keywords: | sodium femlate porosity osmotic pump tablets HPLC bioavailability pharmacokinetics |
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