| 13-正丙基巴马汀的抗心律失常作用 |
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| 引用本文： | 赵树仪,袁玲.13-正丙基巴马汀的抗心律失常作用[J].中国药理学通报,1992,8(6):448-451. |
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| 作者姓名： | 赵树仪 袁玲 |
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| 作者单位： | 天津市医药科学研究所药理二室 天津300070
(赵树仪，祝君梅)，天津市医药科学研究所同位素室 天津300070
(袁玲，卢永梅，张文，李明润)，天津市医药科学研究所药理二室 天津300070(蒋燮荣) |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | iv13—正丙基巴马汀(13—n—Ptopyl—Pal-matine)8mg·kg~(-1)能显著减少氯仿诱发小鼠室颤的发生率.提高哇巴因致豚鼠室早、室速、室颤及心搏停止的阈剂量。iv1、3 mg·kg~(-1)可明显减少CaCl_2诱发小鼠心律失常的发生率.缩短BaCl_2诱发大鼠心律失常的持续时间、但对乌头碱诱发大鼠心律失常无明显的对抗作用。此外,13—正丙基巴马汀还能明显提高大鼠心肌细胞膜Na~+,K~+—ATP酶的活性。
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| 关 键 词： | 哇巴因 乌头碱 BaCl_2 CaCl_2 氯仿Na~+ K~+—ATP酶 |
Antiarrhythmic effects of 13 - n - Propyl-Palmatine |
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| ZHAO Shu-Yi,ZHU Jun -Mei JIANG Xie-Rong.Antiarrhythmic effects of 13 - n - Propyl-Palmatine[J].Chinese Pharmacological Bulletin,1992,8(6):448-451. |
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| Authors: | ZHAO Shu-Yi ZHU Jun -Mei JIANG Xie-Rong |
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| Abstract: | Intravenous injection of 13
-n-Propyl-Palmatine 8 mg · kg-1 reduced markedly the incidence of VF induced by chlorofom in the mice,elevated the threshold doses of Ouabain induced VP,VT,VF,CA in guinea pigs. Iv 1, 3mg · kg-1 reduced signifi
- cantly the incidence of arrhythmia induced by CaCl2 in the mice,shortened the total duration of arrhythmia induced by BaCl3 in the
rats. However, it was not so effective on A-conitine - induced arrhythmia in the rats. In addition, 13 - n - Propyl - Palmatine elevated significantly the activities of Na+, K+ - AT-Pase in the myocardial cellular membranes of rats. |
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| Keywords: | ouabain aconitine BaCL_2 CaCL_2 chloroform Na~+ K~+ -ATPase |
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