| HPLC法测定注射用艾迪(冻干)中紫丁香苷的含量 |
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| 引用本文： | 王晓辉,李清,程维明,王志伟,陈晓辉,毕开顺. HPLC法测定注射用艾迪(冻干)中紫丁香苷的含量[J]. 沈阳药科大学学报, 2006, 23(12): 782-784 |
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| 作者姓名： | 王晓辉 李清 程维明 王志伟 陈晓辉 毕开顺 |
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| 作者单位： | 沈阳药科大学,药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的建立注射用艾迪(冻干)中紫丁香苷的含量测定方法。方法采用HPLC法,色谱柱为Zorbax C18柱(250 mm×4.6 mm,5μm),流动相为乙腈水(体积比为9∶91),检测波长为265 nm,柱温为40℃。结果紫丁香苷在5.35~26.75 mg.L-1内峰面积与质量浓度呈良好的线性关系,相关系数为0.999 8,平均回收率为99.7%,RSD为2.0%(n=9)。结论采用HPLC法测定注射用艾迪(冻干)中紫丁香苷的含量可作为注射用艾迪(冻干)质量控制的指标。
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| 关 键 词： | 注射用艾迪(冻干) 紫丁香苷 高效液相色谱法 含量测定 |
| 文章编号： | 1006-2858(2006)12-0782-03 |
| 收稿时间： | 2006-02-21 |
| 修稿时间： | 2006-02-21 |
Determination of syringin in Aidi freezing dried powered injection by HPLC |
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| WANG Xiao-hui,LI Qing,CHENG Wei-ming,WANG Zhi-wei,CHEN Xiao-hui,BI Kai-shun. Determination of syringin in Aidi freezing dried powered injection by HPLC[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(12): 782-784 |
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| Authors: | WANG Xiao-hui LI Qing CHENG Wei-ming WANG Zhi-wei CHEN Xiao-hui BI Kai-shun |
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| Abstract: | Objective To establish an HPLC method for the determination of syringin in Aidi freezing dried powered injection.Methods Chromatographic assay was performed on Zorbax C_(18)(250 mm×(4.6 mm) ID,5 μm)column with acetonitrile-water(V∶V=9∶91) as mobile phase.The flow rate was(1.0 mL·min~(-1)) and the detection wavelength was set at 265 nm.Results Syringin had a good linearity(r=0.999 8) in the range of 5.35-26.75 mg·L~(-1).The mean recovery was 99.7%,and RSD=2.0%(n=9).Conclusions The method is simple,sensitive and accurate.It can be used for quality control of Aidi freezing dried powered injection. |
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| Keywords: | Aidi freezing dried powered injection syringin HPLC content determination |
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