微生态制剂治疗388例急性腹泻患儿的临床研究

目的比较多西他赛在不同时间点给药后的血药浓度、疗效以及毒性反应的变化,根据其节律变化选择临床最佳给药时间,获得最佳疗效。方法经病理和细胞学证实的60例III、IV期非小细胞肺癌(NSCLC)患者随机分为3组。多西他赛:A组(n=20)在8∶00 am给药,B组(n=20)在2∶00 pm给药,C组(n=20)在8∶00 pm给药;顺铂在多西他赛给药后第2天给予。多西他赛40 mg.m-2,ivgtt,d1,8;顺铂75 mg.m-2,ivgtt,d1,第21天重复。测定给药后1,10,24 h的血药浓度,并评价经化疗2个周期后的疗效和不良反应。结果3组的疗效和血药浓度在统计学上没有显著性差异,但2:00 pm,8:00 pm给药组的不良反应发生率较高。结论多西他赛治疗NSCLC在8∶00 am给药较为安全有效,可增加病例数做进一步的深入研究。

Study of Therapeutic Effect of Microecological Preparation in 388 Acute Children Diarrhea Patients

OBJECTIVE Microbioecological preparation has certain therapeutic effect on infant diarrhea. METHODS All of 388 cases of acute infant diarrhea were randomly divided into 2 groups. The treatment group used microbioecological preparation + conventional therapy. To observe the therapy effect, length of hospital stay, and the cost of treatment. RESULTS The average length of hospital can be shorten, the average cost of treatment can be saved in the treatment group (P<0.05). CONCLUSION Microbioecological preparation on acute infant diarrhea has significance effect and can shorten the length of hospital stay, save the cost of treatment, reduce hospital cross-infection and reduce the suffering of children.