无症状气道高反应性与血清特异性IgE及血清嗜酸细胞？…

目的 探讨无症状气道高反应性与血清特异性ＩｇＥ（ｓＩｇＥ）及嗜酸细胞阳离子蛋白（ＥＣＰ）的相关性。方法 对１１２３名无哮喘病史的１１～１４岁在校学生用组胺吸入激发试验（计量法）进行了气道反应性普查，对４１名出现气道高反应性者进一步检查了ｓＩｇＥ及ＥＣＰ，同时随机选择了３１名气道反应性正常的学生作为对照组。结果 １１２３名学生有４１例出现气道高反应性，阳性率为４％。有哮喘家族史的学生气道高反应性阳性

Correlation of asymptomatic bronchial hyperresponsiveness with serum specific IgE and eosinophilic cation protein

OBJECTIVE: To explore the correlation of asymptomatic bronchial hyperresponsiveness with serum specific IgE(sIgE) and eosinophilic cation protein(ECP). METHODS: Histamine inhalation provoking test (quantitative method) was used in a survey for bronchial responsiveress in 1,123 students aged between 11 to 14 years old, 41 individuals with asymptomatic bronchial hyperresponsiveness received further test for sIgE and ECP. 31 students with normal bronchial responsiveness were randomly selected as the control. RESULTS: 4%(41/1,123) of the students showed bronchial hyperresponsiveness. The incidence of bronchial hyperresponsiveness with family history of asthma (11/14, 79%) was higher than that without a family history (30/1,109, 3%), with statistical significance (P < 0.005). The positive rates for sigE (90%, 37/41, P < 0.01) and ECP (17%, 7/41, P < 0.05), sIgE q value (14.3 +/- 12.1) micrograms/L, (P < 0.01) and ECP value (44.3 +/- 60.2) micrograms/L, (P < 0.01) in asymptomatic bronchial hyperresponsiveness group were higher than those of the control with statistical significance. His PD20-FEV1 was negatively related to aIgE q value (P < 0.05) and not related to ECP (P > 0.05). CONCLUSION: The asymptomatic bronchial hyperresponsiveness was closely related to allergy but not to ECP. Those with a family history of asthma, or with positive sIgE should be followed.