A new [2H]‐labelled α‐trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates |
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| Authors: | Georg Heinkele Mirjam C. K. Geditz Boian Ganchev Reinhold Kerb Ute Hofmann Thomas E. Mürdter |
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| Affiliation: | Dr. Margarete Fischer‐Bosch Institute of Clinical Pharmacology and University of Tuebingen, Auerbachstrasse 112, 70376 Stuttgart, Germany |
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| Abstract: | A new reaction pathway for the synthesis of a [2H]‐labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope‐labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis. |
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| Keywords: | 2,3,4‐[2H3]‐6‐Methyl‐2,3,4‐tri‐O‐isobutyryl‐1‐O‐trichloroacetimidoyl‐α ‐d‐glucopyranuronate glucuronidation stable isotope‐labelled internal standard 2′ ,3′ ,4′ ‐[2H3]‐Dihydroartemisinin‐12α ,1′ β ‐glucuronide 2′ ,3′ ,4′ ‐[2H3]‐Clomiphene‐4‐O‐1′ β ‐glucuronide |
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