Error processing and impulsiveness in normals: evidence from event-related potentials

Electrophysiological correlates of impulsiveness were investigated in thirty-two healthy subjects using event-related potentials (ERP). Impulsiveness was determined by calculating individual reaction times (as a function of general response speed) in order to split the entire group into two subgroups with a more controlled (n = 16) and less controlled (n = 16) response style. Participants performed a Go/Nogo task while a 64 channel EEG was recorded. Artifact-free EEG segments were used to compute ERPs on correct Go trials and incorrect Nogo trials, separately. Three ERP components were of special interest: the error-related negativity (ERN)/error negativity (Ne) and the "early" error positivity (Pe) reflecting automatic error processing and the "late" error positivity (Pe) which is thought to mirror the awareness of erroneous responses. Subjects with higher impulsiveness showed smaller amplitudes than subjects with lower impulsiveness for the ERN/Ne component and the "early" Pe component. With regard to the "late" Pe groups did not differ. Hence, ERP measures appear suitable for detailed analyses of impulsiveness in healthy participants. Moreover, present results argue for the necessity of careful control of impulsiveness when including normal comparison groups in the context of clinical studies.