| 奥氮平与氯丙嗪治疗精神分裂症比较研究 |
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| 引用本文： | 贺津,安庆华. 奥氮平与氯丙嗪治疗精神分裂症比较研究[J]. 精神医学杂志, 2003, 16(2): 78-80 |
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| 作者姓名： | 贺津 安庆华 |
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| 作者单位： | 山东省滨州市人民医院精神卫生中心 256613(贺津)，山东省滨州市人民医院精神卫生中心 256613(安庆华) |
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| 摘 要： | 目的 评价奥氮平治疗精神分裂症的临床疗效与安全性。方法 对 80例精神分裂症患者随机分成两组 ,分别给予奥氮平与氯丙嗪治疗 8周 ,采用PANSS评价临床疗效 ,TESS评价不良反应。结果 奥氮平组治疗前后PANSS减分率为 4 2 .4 % ,有效率为 82 .5 % ;氯丙嗪组治疗前后PANSS减分率为 37.5 % ,有效率为 70 %。奥氮平组未见严重的药物不良反应 ,安全性好。结论 奥氮平治疗精神分裂症有效性好、安全性高、可行性强
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| 关 键 词： | 精神分裂症 奥氮平 氯丙嗪 |
| 文章编号： | 1009-7201(2003)-02-0078-03 |
| 修稿时间： | 2003-01-15 |
A comparative trial of olanzapine versus chlorpromazine in the treatment of schizophrenia |
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| He Jin,An Qinghua. A comparative trial of olanzapine versus chlorpromazine in the treatment of schizophrenia[J]. Journal of Psychiatry, 2003, 16(2): 78-80 |
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| Authors: | He Jin An Qinghua |
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| Affiliation: | He Jin,An Qinghua.The People's Hospital of Binzho,Shandong 256613,China |
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| Abstract: | Objective To evaluate the efficacy and safety of olanzapine in the treatment of schizophrenia.Methods 80 patients with schizophrenia were assigned into olanzapine group and chlorpromazine group for 8 weeks.PANSS and TESS scales were used to measure the efficacy and safety.Results The effective rates of olanzapine and chlorpromazine were 82.5% and 70.0%respectively.The reduction rates of PANSS total score in olanzapine and chlorpromazine were 42.4% and 37.5% respectively.There were significant differences in effective rate and reduction rate between two groups.No severe side effect was found in olanzapine group.Conclusion Olanzapion was effective,safe and feasible to treat schizophrenia. |
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| Keywords: | Schizophrenia Olanzapine Chlorpromazine |
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