Prognostic value of EGFR family expression in lymph node-negative esophageal squamous cell carcinoma patients |
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| Authors: | Weiwei Yu Xi Yang Li Chu Kuaile Zhao Haiquan Chen Jiaqing Xiang Yawei Zhang Hecheng Li Weixin Zhao Menghong Sun Qiao Wei Xiaolong Fu Congying Xie Zhengfei Zhu |
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| Affiliation: | 1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China;2. Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People''s Hospital, Shanghai, China;3. Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China;4. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China;5. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;6. Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China;g. Radiotherapy and Chemotherapy Department, the 1 st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China |
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| Abstract: | The human epidermal growth factor receptor (EGFR) family has been widely studied in cancer, however, the prognostic role of EGFR family expression in lymph node-negative esophageal squamous cell carcinoma (ESCC) patients have not been invalidated. This study was designed to determine the prognostic value of EGFR family expression in a population of lymph node-negative ESCC patients treated with curative resection. EGFR family protein expression was examined by immunohistochemical analysis of tissue microarrays of 94 patients with lymph node-negative ESCC after radical esophagectomy with three-field lymphadenectomy. Survival differences were compared using Kaplan–Meier analysis. Cox regression analyses were performed to determine the prognostic factors for overall survival and disease-free survival (DFS). ErbB4 expression was found to be an independent prognostic factor for DFS in patients without lymph node metastasis; increased ErbB4 expression was associated with decreased DFS. Additionally, patients with high ErbB4 expression tended to have worse overall survival. EGFR, ErbB2 and ErbB3 expression were not significantly associated with survival in lymph node-negative ESCC patients. Increased ErbB4 immunohistochemical expression was associated with poor prognosis in lymph node-negative ESCC patients. |
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| Keywords: | Esophageal cancer Esophageal squamous cell carcinoma Epidermal growth factor receptor Prognostic factor Lymph node-negative |
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