Expression of ILT3 predicts poor prognosis and is inversely associated with infiltration of CD45RO+ T cells in patients with colorectal cancer |
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| Authors: | Jie Liu Chun-xiao Lu Fang Zhang Wei Lv Chuanyong Liu |
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| Affiliation: | 1. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China;2. Department of Oncology, WeiFang Medical University, Weifang, Shandong, China;3. Department of Pharmacy, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China |
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| Abstract: | Immunoglobulin like transcript 3 (ILT3) was previously identified as an inhibitory receptor to induce T cell anergy in tranplantation, autoimmunity and allergy. Here we aimed to investigate the expression of ILT3 in colorectal cancer, analyze the association between ILT3 expression and clinicopathological variables and prognosis, and evaluate the correlation between the expression of ILT3 and CD45RO+ T cells density. Expression of ILT3 was identified on the cell membrane and/or in the cytoplasm. High expression ILT3 was identified in 55 of 85 (64.7%) tumor specimens, which was significantly higher than that in the adjacent normal tissues(5/30) (P?
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| Keywords: | ILT3 Colorectal cancer Prognosis CD45RO |
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