The expression of IMP3 in 366 cases with ovarian carcinoma of high grade serous,endometrioid and clear cell subtypes |
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| Authors: | Linghui Lu Shunni Wang Qin Zhu Yuqing Qu Weiyong Gu Yan Ning Xiaochen Chen Yiqin Wang |
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| Affiliation: | Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, No. 128, Shenyang Road, 200090, Shanghai, China |
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| Abstract: | The clear cell (CCC), high grade serous (HGSC) and endometrioid (EC) ovarian carcinomas share overlapping histological features. The oncogene IMP3 is implicated in CCC with an elusive utility in differential diagnosis. We collected 366 cases with ovarian primary carcinomas to detect IMP3, Napsin-A and HNF-1β by immunochemistry. In 351 cases, the positive expression rate of IMP3 in CCC was significantly higher than that either in EC or HGSC (p?p?p?p?p?
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| Keywords: | IMP3 Napsin-A HNF-1β Ovarian clear cell carcinoma Immunocytochemistry |
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