| SINGIFICANCE OF SIMULTANEOUS STUDY ON MORPHOLOGY,IMMUNOLOGY, CYTOGENETICS,GENOTYPE AND CLINICAL PRESENTATION IN CHILDHOOD ACUTELYMPHOBLASTICLEUKEMIA |
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| 引用本文： | 顾龙君,陈竺,钱珠兹,张影梅,叶裕春,陈英,谢竞雄. SINGIFICANCE OF SIMULTANEOUS STUDY ON MORPHOLOGY,IMMUNOLOGY, CYTOGENETICS,GENOTYPE AND CLINICAL PRESENTATION IN CHILDHOOD ACUTELYMPHOBLASTICLEUKEMIA[J]. 上海第二医科大学学报, 1992, 0(2) |
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| 作者姓名： | 顾龙君 陈竺 钱珠兹 张影梅 叶裕春 陈英 谢竞雄 |
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| 作者单位： | Department of Pediatrics，Xinhua Hospital，SSMU，Shanghai，Shanghai Institute of Hematology，SSMU，Shanghai，Shanghai Children's Hospital，Shanghai，Department of Pediatrics，Ruijin Hospital，SSMU，Shanghai，Department of Pediatrics，Xinhua Hospital，SSMU，Shanghai，Department of Internal Medicine，Renji Hospital，SSMU，Shanghai，Department of Pediatrics，Xinhua Hospital，SSMU，Shanghai |
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| 摘 要： | By means of a series of monoclonal antibodies, gene probes of immanoglobulin aheavy chain (IgH), T cell receptor (TCR) gamma and delta chain as well as chromosome karyotype analysis, the immunophenotype and karyotype were studied in 23 children with acute lymphoblastic leukemia (ALL) diagnosed according to FAB classification criteria and genotype in 21 of them. Among them 16 cases belonged to B lineage ALL, 4 cases to T-ALL, one case to ANLL, and 2 cases to acute undifferential leukemia (AUL). The IgH gene rearrangement was expressed in all of the B lineage ALL, the T-ALL were in germline. The gene rearrangement of TCR gamma and delta chain was expressed in both type of ALL, but the form of rearrangement was different. The quantitative abnormalities of chromosomes were found in 11 of 23 cases, 2 cases had chromosome structure abnormalities. Correlating with clinical manifestations it was found that some relationship between morphology (M), immunology (I), cytogeneties (C), genotype and clinical manifestations in type B-Ⅳ, T-ALL, and A UL exieted, indicating that they had great significance in refining subclassification, prognosis and guidance of treatment in childhood ALLs.
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SINGIFICANCE OF SIMULTANEOUS STUDY ON MORPHOLOGY, IMMUNOLOGY, CYTOGENETICS, GENOTYPE AND CLINICAL PRESENTATION IN CHILDHOOD ACUTELYMPHOBLASTICLEUKEMIA |
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| Gu Longjun Chen Zhu,Qian Zhuci Zhang Yingmei,Ye Yuchun,Chen Ying Xie Jingxiong. SINGIFICANCE OF SIMULTANEOUS STUDY ON MORPHOLOGY, IMMUNOLOGY, CYTOGENETICS, GENOTYPE AND CLINICAL PRESENTATION IN CHILDHOOD ACUTELYMPHOBLASTICLEUKEMIA[J]. Journal of Shanghai Second Medical University(Foreign Language Edition), 1992, 0(2) |
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| Authors: | Gu Longjun Chen Zhu Qian Zhuci Zhang Yingmei Ye Yuchun Chen Ying Xie Jingxiong |
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| Affiliation: | Gu Longjun Chen Zhu,Qian Zhuci Zhang Yingmei,Ye Yuchun,Chen Ying Xie Jingxiong Department of Pediatrics,Xinhua Hospital,SSMU,Shanghai Shanghai Institute of Hematology,SSMU,Shanghai Shanghai Children's Hospital,Shanghai Department of Pediatrics,Ruijin Hospital,SSMU,Shanghai Department of Internal Medicine,Renji Hospital,SSMU,Shanghai |
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| Abstract: | |
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| Keywords: | ALL immunphenotype IgH gene rearrangement TCR gene rearrangement karyotype |
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