培门冬酶注射液致过敏性休克

1例63岁男性患者,确诊“非霍奇金淋巴瘤、ALK阴性间变大细胞型、Ⅰ期B”38 d,既往无药物和食物过敏史.治疗期间在第三次使用培门冬酶注射液3750IU分三个部位匀速肌肉注射90 min后,患者出现前胸、后背部、臀部及双上肢风团,诉奇痒无比,60 min后患者入厕时诉剧烈头痛、胸痛、咽喉痛,舌尖麻木,视物模糊,血压降低,无呼吸困难.立即给予抗过敏、扩充血容量治疗,30 min后症状缓解,仍有皮肤斑片状风疹.1d后症状完全消失,其余药物继续使用,未再发生类似反应.

Allergic shock induced by L-asparaginase enzyme injection

One 63-year-old male patient was diagnosed as non Hodgkin lymphoma, ALK negative anaplastic large cell type I B for 38 days. The patient has no drug and food allergy history. During the treatment, the chest, back, buttocks and upper limbs wheal were itchy when L-asparaginase enzyme injection 3750 IU was injected on three parts of uniform muscles in the third time after 90 minutes. After 60 minutes, when the patient went to toilet, he was suffered from severe headache, chest pain, sore throat, tongue numbness, blurred vision, decreased blood pressure, without dyspnea. Immediately, he was given allergy, expand blood volume therapy, after 30 minutes, the patient had his remission from the symptoms. Even though, there was still patchy rubella skin. One day later, all the symptoms disappeared completely. All medicine were kept using and there was no longer similar reaction.