注射用萘夫西林、病毒唑配伍使用致儿童药物性溶血性贫血12例分析

目的 对临床儿童使用注射用萘夫西林、病毒唑配伍致药物性溶血性贫血12例进行分析研究,为临床提供安全性用药依据.方法 对我院2011年7月～8月门诊儿科使用注射用萘夫西林情况进行统计分析,对期间发生药物性溶血性贫血(DHA)不良反应进行分析、研究、评估.结果 0～5岁儿童因抗感染而使用注射用萘夫西林、病毒唑配伍致药物性溶血性贫血发生率为3.3％,平均发生时间为5.5天,其中男童发生率2.39％,女童发生率5％.结论 萘夫西林、病毒唑联合使用应谨慎.对于儿童,尤其是低龄儿童应特别注意严格按照说明书推荐的给药次数用药.

Aanlysis of 12 Cases of Children Drug-induced Hemolytic Anemia Caused by Nafcillin and Ribavirin Combination

Objective To analyze and discuss the drug-induced hemolytic anemia on children caused by the combined use of the injections of nafciUin, ribavirin in 12 cases in clinical, and provide evidence for clinical safe use of medicine. Methods The uses of the injectable nafcillin in pediatric outpatient department of our hospital between July and August in 2011 were statistically analyzed, and the adverse reactions of drug-induced hemolytic anemia（DHA） occuring during these were analyzed, researched and assessed. Results The adverse reactions of the drug-induced hemolytic anemia caused by the combination uses of the injectable nafcillin, ribavirin due to resistance to infections on children beween 0-5 years old occurred at a rate of 3.3%, and the average time was 5.5 days, the boys incidence rate was 2.39%, and girls incidence rate was 5%. Conclusion Nafcillin, ribavirin combined use should be cautious. For the children, especially younger children should be paid attention strictly in accordance with the instructions to the recommended medication.