| 复方红景天制剂提高小鼠运动耐力的实验研究 |
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| 引用本文： | 徐荣,葛华,王永新.复方红景天制剂提高小鼠运动耐力的实验研究[J].中国药物应用与监测,2012,9(2):78-80. |
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| 作者姓名： | 徐荣 葛华 王永新 |
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| 作者单位： | 1. 空军总医院药学部,北京,100142
2. 空军航空医学研究所,北京,100142 |
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| 基金项目： | 国家科技重大专项（2010Zx09102-204）;国家自然科学基金项目（81072914,81073083） |
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| 摘 要： | 目的:研究复方红景天制剂对小鼠的抗疲劳作用.方法:将SPF级昆明种小鼠随机分成复方红景天制剂低、中、高剂量组和阴性对照组.每日灌胃1次,连续30 d后,分别测定小鼠负重游泳时间、血清尿素、肝糖原和血乳酸的含量.结果:与阴性对照组相比,复方红景天制剂可以延长小鼠负重游泳时间(P＜0.05),明显增加肝糖原含量(P＜0.01),显著降低运动小鼠的血乳酸含量(P＜0.01).各剂量组小鼠血清尿素浓度无显著性差异(P＞0.05).结论:复方红景天制剂具有抗疲劳作用.
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| 关 键 词： | 复方红景天制剂 抗疲劳 动物实验 |
The effect of Rhodiola Compound on improving exercise tolerance in mice |
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| Authors: | XU Rong GE Hua WANG Yong-xin |
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| Institution: | 1. Department of Pharmacy, General Hospital of the Air Force, Beijing 100142, China; 2. Institute of Aviation Medicine, Air Foree, Beijing 100142, China) |
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| Abstract: | Objective： To study the anti-fatigue function of Rhodiola Compound in mice. Methods： Kuming mice （SPF） were randomly divided into low-dose, medium-dose, high-dose group of Rhodiola Compound and negative control group. Mice were administered once daily for 30 days. The loaded-swimming time, serum urea, hepatic glycogen and lactic acid level in blood were measured. Results： Compared with negative control group, the time of loading swimming （P 〈 0.05） and the content of hepatic glycogen （P 〈 0.01） were significantly increased in Rhodiola Compound group. The lactic acid level in blood was significantly reduced in Rhodiola Compound group （P 〈 0.01）. There was no significant difference in concentration of serum urea among the groups （P 〉 0.05）. Conclusion： Rhodiola Compound could alleviate physical fatigue in mice. |
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| Keywords: | Rhodiola Compound Anti-fatigue Animal experiment |
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