3 岁以内肺炎患儿血清维生素A水平研究

目的 探讨肺炎患儿维生素A（VA）水平与肺炎严重程度及反复呼吸道感染（RRI）的关系，为VA 水平作为肺炎病情判断及反复呼吸道感染风险预测提供理论基础。方法 选取88 例3 岁以下的肺炎患儿为研究对象，检测入院时血清VA 水平，并随访出院后1 年的RRI 发生情况。结果 88 例肺炎患儿的血清VA 水平为0.8±0.3 μmol/L，其中维生素A 缺乏（VAD）的35 例（40%，35/88）。重症肺炎组血清VA 水平低于轻症肺炎组（0.7±0.3 μmol/L vs 0.9±0.3 μmol/L），P P P 0.05）。结论 肺炎患儿VA 水平高低与病情严重程度及反复呼吸道感染的发生相关。

Serum level of vitamin A in children with pneumonia aged less than 3 years

ObjectiveTo investigate the association of the serum level of vitamin A (VA) with the severity of pneumonia and recurrent respiratory infection (RRI) within one year after treatment in children with pneumonia, and to provide a basis for serum VA level used as an index for judgment of the condition of pneumonia and prediction of the risk of recurrent respiratory infection.MethodsA total of 88 children with pneumonia aged less than 3 years were enrolled as study subjects. Serum VA level was measured on admission, and the development of RRI was followed up by telephone within 1 year after discharge.ResultsThe children with pneumonia showed a reduction in the serum level of VA (0.8±0.3 μmol/L). The severe pneumonia group had a signiifcantly lower serum level of VA than the mild pneumonia group (0.7±0.3 μmol/L vs 0.9±0.3 μmol/L;P<0.05), as well as a signiifcantly higher detection rate of vitamin A deifciency (VAD) than the mild pneumonia group (63% vs 28%;P<0.05). The children were followed up for 1 year. The VAD-pneumonia group showed a signiifcantly higher incidence of RRI than the normal VA-pneumonia group (49%vs 18%;P<0.05), while there were no signiifcant differences in the incidence of RRI between the suspected subclinical vitamin A deifciency (SSVAD)-pneumonia group and the normal VA-pneumonia group, as well as between the VAD-pneumonia group and the SSVAD-pneumonia group (P>0.05).ConclusionsChildren with pneumonia often have a low level of VA, and the level of VA is associated with the severity of pneumonia and the development of RRI afterwards.