血流感染儿童维生素D营养状况的评价

目的 观察血流感染患儿与健康儿童血清25(OH)D 水平的差别。方法 采用病例对照研究方法,选取2010 年1 月至2013 年12 月间住院治疗且双份血培养阳性的60 例血流感染患儿为血流感染组,另选取60 例同年龄段同时期行健康体检的儿童为健康对照组。化学发光法检测两组儿童血清25(OH)D 水平,比较两组儿童不同水平25(OH)D 的构成比。结果 血流感染组患儿血清25(OH)D 水平明显低于健康对照组(P<0.01);血流感染组维生素D 正常(8%)、不足(22%)的构成比均显著低于健康对照组(分别为35%、43%,P<0.05),而缺乏(42%)、严重缺乏(28%)的构成比均显著高于健康对照组(分别为13%、8%,P<0.01)。结论 维生素D 不足在儿童中普遍存在,血流感染患儿血清25(OH)D 水平显著低于健康儿童。

Vitamin D level in children with bloodstream infection

Objective To investigate the difference in serum 25(OH)D level between children with bloodstream infection and healthy children. Methods A case-control study was conducted among 60 children with bloodstream infection who were hospitalized between January 2010 and December 2013 and had positive results of two blood cultures. Meanwhile, 60 aged-matched healthy children who underwent physical examination during the same period of time were enrolled as the healthy control group. Chemiluminescence was applied to measure the serum 25(OH)D level, and the constituent ratios of children with different serum 25(OH)D levels were compared between the two groups. Results The bloodstream infection group had a significantly lower serum 25(OH)D level than the healthy control group (P<0.01). Compared with the healthy control group, the bloodstream group had significantly lower constituent ratios of children with normal Vitamin D level (8% vs 35%) or vitamin D insufficiency (22% vs 43%) (P<0.05). Compared with the healthy control group, the bloodstream group had significantly higher constituent ratios of children with vitamin D deficiency (42% vs 13%) or severely vitamin D deficiency (28% vs 8%) (P<0.01). Conclusions Vitamin D insufficiency prevails among children, and children with bloodstream infection have a significantly lower serum 25(OH) D level than healthy children.