A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles |
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| Authors: | Bilia Anna Rita Bergonzi M Camilla Vincieri Francesco F Lo Nostro Pierandrea Morris Gareth A |
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| Institution: | Department of Pharmaceutical Sciences, University of Florence, via Gino Capponi 9, 50121 Firenze, Italy. |
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| Abstract: | Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. |
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