调脂治疗对增强肥胖2型糖尿病患者胰岛素敏感性的疗效观察

目的:提高糖尿病患者的达标率,减少胰岛素用量.方法:测定普伐他汀治疗前后病人的空腹血糖、餐后2h血糖、糖化血红蛋白、空腹胰岛素水平,计算胰岛素敏感指标(ISI).结果:调脂治疗组6周后ISI上升较对照组差异有显著性(P＜0.05),空腹血糖及餐后血糖治疗组与对照组均有下降,但无统计学意义.治疗组空腹胰岛素和C肽治疗后较前明显下降,差异有显著性(P＜0.05).结论:经调脂治疗后病人ISI增加有显著性,血糖达标后胰岛素用量明显减少.

Lipid-adjusting Therapy can Enforce Insulin Sensitivity of Type 2 Diabetes Mellitus Patients with Obesity

Objective:To increase the rate of glucose control and to reduce the dose of insulin.Method:Serum fasting glucose,post load glucose,glycosylated hemoglobin and fasting insulin were measured before pravastatin therapy and afeter therapy respectively,and calculated the insulin sensitivity index(ISI).Result:After lipid-adjusting therapy for six weeks,there was a significant increase in ISI in therapy groop compared to control groop.Serum fasting glucose and post load glucose in both groop all decreased,and had no significance.Serum fasting insulin and C peptide were decreased after treatment,there was a significance between two groops.Conclusion:There were significant insulin sensitivity index in lipid-adjusting group than in controls.The dose of insulin was reduced obviously after good glucose control.