| Abstract: | Intravenous synthetic a-human atrial na-triuretic polypeptide (a-hANP) 300 pLg wasgiven to three normal volunteers resulting in asignificant increase of urine volume and sodium,potassium and chloride excretion. This peptidealso caused a fall in blood pressure, cardiac out-put and stroke volume, accompanied by an in-crease in heart rate. The plasma aldosteronelevel elevated and renin activity incrcascd at 0.5t0 2 hours after injection. a-hANP is a 28-amino acidpolypeptideisolated from human atrial tissue.lWe haveshown by intravenous injection ofsynthetica-hANP that it is a potent diuretic,natriureticand induces depressor responses in rats.2 Thepresent study examines the pharmacological effects of a-hANP on healthy subjects. |
