| 重组人白细胞介素3和白细胞介素6对骨髓基质细胞生长的调节作用 |
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| 引用本文： | 郝思国,杨吉成,邹正辉,盛伟华,张硕.重组人白细胞介素3和白细胞介素6对骨髓基质细胞生长的调节作用[J].安徽医科大学学报,1998(6). |
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| 作者姓名： | 郝思国 杨吉成 邹正辉 盛伟华 张硕 |
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| 作者单位： | 安徽医科大学第一附属医院血液科，苏州医学院基因工程研究室，苏州医学院基因附属二院血液科，安徽省合肥国家建材局水泥研究院卫生所 |
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| 摘 要： | 目的了解重组人白细胞介素３（ｒｈＩＬ－３）和重组人白细胞介素６（ｒｈＩＬ－６）对骨髓造血微环境的调节作用。方法应用成纤维细胞体外集落形成法，观察了ｒｈＩＬ－３和ｒｈＩＬ－６对成纤维细胞集落（ＣＦＵ－Ｆ）体外生长的影响。结果ｒｈＩＬ－３和ｒｈＩＬ－６能显著地刺激ＣＦＵ－Ｆ的生长，两者联合应用时对ＣＦＵ－Ｆ生长的刺激作用明显强于两者单用，表现出协同效应。结论ｒｈＩＬ－３和ｒｈＩＬ－６可促进基质细胞生长，对促进化疗和（或）放疗及骨髓移植后造血微环境的恢复和重建具有重要的临床应用潜能
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| 关 键 词： | 白细胞介素3 白细胞介素6 成纤维细胞 骨髓 |
Regulative effects of rhIL 3 and rhIL 6 on proliferation of stromal cells from marrow |
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| Hao Siguo,Yang Jicheng,Zou Zhenghui et al.Regulative effects of rhIL 3 and rhIL 6 on proliferation of stromal cells from marrow[J].Acta Universitis Medicinalis Anhui,1998(6). |
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| Authors: | Hao Siguo Yang Jicheng Zou Zhenghui |
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| Abstract: | Objective To determine the regulative effects of recombinant human interleukin 3(rhIL 3) and interleukin 6(rhIL 6) on bone marrow hematopoietic microenvironment. Methods The effects of rhIL 3 and rhIL 6 on proliferation of colony forming Unit Fibroblasts (CFU F) were studied in vitro CFU F culture system. Results Both of these interleukins can promote the proliferation of CFU F in vitro with a dosage dependence, meanwhile, the synergistic effects between rhIL 3 and rhIL 6 on proliferation of cells from CFU F were observed. Conclusion The findings suggested that rhIL 3 and rhIL 6 may promote the proliferation of marrow stromal cells,which may be helpful for recovery and reconstitution of hematopoietic microenvironment after intensive chemotherapy and bone marrow transplantation. |
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| Keywords: | interleukin 3 interleukin 6 fibroblasts bone marrow |
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