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T(8;21) with a phenotype of chronic myeloid leukemia
Authors:W H Raskind  T Papayannopoulou  W P Hammond
Affiliation:Department of Medicine, University of Washington School of Medicine, Seattle 98195.
Abstract:A myeloproliferative disorder having the phenotype of chronic myeloid leukemia (CML) with t(8;21) is reported. Neither t(9;22) nor a DNA rearrangement in the bcr region was detected. The presence of t(8;21), in contrast with previous experience, does not appear to prevent full maturation of the granulocytic series.
Keywords:myelodysplasia  myeloproliferative disorder  chromosome alterations  cytogenetic abnormalities
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