| 中药防治硫酸镍对Ca2+-ATP酶及钙调素活性抑制的实验研究 |
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| 引用本文： | 朱玉真,赵健雄,王学习,孙应彪,宁守斌.中药防治硫酸镍对Ca2+-ATP酶及钙调素活性抑制的实验研究[J].中国职业医学,2001,28(5):21-22. |
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| 作者姓名： | 朱玉真 赵健雄 王学习 孙应彪 宁守斌 |
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| 作者单位： | 兰州医学院中西医结合研究所,甘肃,兰州,730000 |
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| 基金项目： | 甘肃省自然科学基金资助项目(98112) |
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| 摘 要： | 目的：扶正解毒汤（FJD）防治硫酸镍（NiSO4）对大鼠肝线粒体Ca^2 -ATP酶及钙调素（CaM）活性的抑制作用。方法：Wistar大鼠NiSO4腹腔染毒，FJD灌胃防治，14d后测定线粒体Ca^2 -ATP酶及CaM的活性进行评价。结果：NiSO4致肝脏Ca^2 -ATP酶及CaM活性降低，FJD各防治组均有明显恢复。结论：FJD具防治NiSO4致大鼠肝Ca^2 -ATP酶及CaM活性抑制的作用。
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| 关 键 词： | 扶正解毒汤 硫酸镍 肝 Ca^2＋－ATP酶 CaM |
| 文章编号： | 1000-6486(2001)05-0021-02 |
| 修稿时间： | 2001年1月19日 |
Experimental study on effect of Fu Zheng Jie Du Tang on Ca2+-ATPase and CaM of liver intoxicated by nickel sulfate in rats |
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| ZHU Yu zhen,ZHAO Jian xiong,WANG Xue xi.Experimental study on effect of Fu Zheng Jie Du Tang on Ca2+-ATPase and CaM of liver intoxicated by nickel sulfate in rats[J].China Occupational Medicine,2001,28(5):21-22. |
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| Authors: | ZHU Yu zhen ZHAO Jian xiong WANG Xue xi |
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| Abstract: | Objective To observe the prevention and cure effect of Fu Zheng Jie Du Tang (FJD) on liver tissue injured by nickel sulfate (NiSO 4) in rats. Methods Rats were injected peritoneally with NiSO 4 to make the animal model of nickel poisoning. FJD was used by gastric intubation to cure and protect the liver injury caused by NiSO 4. Results After 14 d of successive administration with FJD, the inhibition of activities of Ca 2 ATPase and CaM in liver showed rather obvious restoration. Conclusion FJD could effectively prevent and cure the inhibition of liver Ca 2 ATPase and CaM by NiSO 4 in rats. |
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| Keywords: | FJD NiSO 4 liver Ca 2 ATPase CaM |
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