短期强化生活方式干预对社区糖调节受损患者的影响

目的观察短期强化生活方式干预对社区糖调节受损患者代谢指标的影响。方法在山西省太原市迎泽区中随机选取糖调节受损患者90例，并随机分为干预组（n=45）和对照组（n=45），对照组给予一般糖尿病健康知识讲座，干预组在此基础上，进行为期3个月的强化生活方式干预。比较干预前后干预组代谢指标，以及干预后干预组和对照组之间指标的差别。结果干预组干预后与干预前相比，口服葡萄糖耐量试验2h血糖（F=13．47，P〈0．05）及胰岛素抵抗指数显著降低（F=82．25，P〈0．05）；干预后干预组与对照组比较，体重指数（t=-2．44，P〈0．05）、收缩压（t=-3．39，P〈0．05）、舒张压（t=-3．97，P〈0．05）、空腹血糖（t=-3．89，P〈0．05）、口服葡萄糖耐量试验2h血糖（t=-7．22，P〈0．05）、总胆固醇（t=-2．72，P〈0．05）、低密度脂蛋白（t=-2．74，P〈0．05）、糖化血红蛋白（t=-3．73，P〈0．05）均明显降低。结论短期强化生活方式干预能显著改善社区糖调节受损患者的多项代谢指标，或延缓代谢指标的恶化进程，此生活方式干预策略适用于山西省太原市的社区居民。

Effects of short-term intensive lifestyle intervention on community patients with impaired glucose regulation

Objective To evaluate the effects of the short-term intervention lifestyle intervention on metabolic measurements of community patients with impaired glucose regulation （IGR）. Methods A total of 90 IGR participants were randomly assigned to the control group （ n = 45 ） or the intervention group （ n = 45 ）. The subjects in the control group received routine diet and physical exercise advice once a month. The subjects in the intervention group received additional individualized diet counseling and circuit-type resistance training. Metabolic parameters were compared before or after the intervention between the two groups. Results In oral glucose tolerance test （OGTF） ,2-h plasma glucose （PG） and homeostasis model of insulin resistance index （HOMA-IR） were significantly decreased in the intervention group at 3 months（ F = 13.47 or 82. 25 ,both P 〈 0. 05 ）. Body mass index （ t = - 2.44, P 〈 0. 05 ）, systolic blood pressure （ t = - 3.39 ,P 〈 0. 05 ） , diastolic blood pressure （ t = - 3.97, P 〈 0. 05 ）, fasting plasma glucose （ t = - 3.89, P 〈0. 05） ,2-h PG （t = -7. 22,P 〈0. 05） ,total cholesterol （t = -2. 72,P 〈0.05） ,low-density lipoprotein cholesterol （t= - 2. 74, P〈 0.05）,and glycosylated hemoglobin A1C （t= - 3.73,P〈 0.05） were significantly declined in the intervention group compared to the control group （ all P 〈 0. 05 ）. Conclusions Intensive lifestyle intervention can significantly improve the metabolic markers of IGR subjects and should be used to prevent type 2 diabetes.