High-dose gadoteridol in MR imaging of intracranial neoplasms. |
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Authors: | V M Runge J E Kirsch V J Burke A C Price K L Nelson G S Thomas B L Dean C Lee |
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Affiliation: | Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky Medical Center, Lexington 40536-0084. |
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Abstract: | Twelve patients with a high suspicion of brain metastases by previous clinical or radiologic examinations were studied in a phase III investigation with magnetic resonance (MR) imaging at 1.5 T after a bolus intravenous injection of 0.1 mmol/kg gadoteridol followed at 30 minutes by a second bolus injection of 0.2 mmol/kg gadoteridol. All lesions were best demonstrated (showed greatest enhancement) at the 0.3-mmol/kg (cumulative) dose, with image analysis confirming signal intensity enhancement in the majority of cases after the second gadoteridol injection. More lesions were detected with the 0.3-mmol/kg dose than with the 0.1-mmol/kg dose, and more lesions were detected with the 0.1-mmol/kg dose than on precontrast images. In this limited clinical trial, high-dose gadoteridol injection (0.3-mmol/kg cumulative dose) provided improved lesion detection on MR images specifically in intracranial metastatic disease. |
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Keywords: | Brain, MR, 10.1214 Brain neoplasms, 10.3634 Brain neoplasms, secondary, 10.38 Contrast enhancement Gadolinium |
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