| 左卡尼汀对尿毒症血透病人营养不良的改善作用 |
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| 引用本文： | 徐洪实,梅长林,张斌,张翼翔,陈蕾. 左卡尼汀对尿毒症血透病人营养不良的改善作用[J]. 中国新药与临床杂志, 2001, 20(1): 41-41 |
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| 作者姓名： | 徐洪实 梅长林 张斌 张翼翔 陈蕾 |
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| 作者单位： | 上海长征医院肾内科上海 200003 |
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| 摘 要： | 目的 :调查尿毒症血透病人的营养状况 ,观察左卡尼汀的治疗作用。方法 :对 30例尿毒症血透病人进行营养分析 ,其中 16例于每次透析后静脉应用左卡尼汀 1g ,共治疗 3mo ,观察营养指标的变化。结果 :尿毒症血透病人饮食蛋白、热量摄入分别为 ( 0 .95±s0 .16)g·kg- 1·d- 1和 ( 113± 2 1)kJ·kg- 1·d- 1,血清前清蛋白为 ( 0 .2 5± 0 .0 5) g·L- 1,血浆游离卡尼汀浓度为 ( 35± 12 ) μmol·L- 1。治疗后 ,血浆游离卡尼汀浓度为 ( 155± 37) μmol·L- 1(P <0 .0 1) ,干体重增加 ,血清清蛋白、前清蛋白也增高。结论 :左卡尼汀可明显纠正血透病人的卡尼汀缺乏 ,改善营养不良
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| 关 键 词： | 尿毒症 血液透析 营养障碍 左卡尼汀 |
| 文章编号： | 1007-7669(2001)01-0041-02 |
Levocarnitine improved malnutrition in hemodialysis patients with uremia |
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| Abstract: | AIM:To evaluate nutrition status and observe effects of levocarnitine on malnutrition in hemodialysis (HD) patients. METHODS: Nutrition status of 30 HD patients were evaluated and levo carnitine 1 g was injected intravenously at the end of each dialysis for 3 mo. Nutrition parameters were examined before and after therapy. RESULTS: In HD patients, dietary protein and calories intake were (0.95± s 0.16) g·kg -1 ·d -1 and (113±21) kJ·kg -1 ·d -1 , respectively. Serum prealbumin and plasma free carnitine were (0.25±0.05) g·L -1 and (35±12) μmol·L -1 . After 3 mo therapy, plasma free carnitine concentration was (155±37) μmol·L -1 . Lean body weight was increased. Serum albumin and prealbumin were elevated. CONCLUSION: Administration of levocarnitine may increase plasma carnitine concentration and improve malnutrition. |
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| Keywords: | uremia hemodialysis nutrition disorders levocarnitine? |
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