不同剂量米非司酮用于紧急避孕效果的观察

目的评价两种小剂量米非司酮用于紧急避孕的临床效果,副反应和对月经的影响。方法将200例无避孕或避孕措施失败,性交后72小时内并要求采用补救措施,防止意外妊娠的健康妇女随机分为组Ⅰ、组Ⅱ,分别服用米非司酮50mg、25mg,门诊服药登记、随访,观察服药后副反应和妊娠情况。结果两组的紧急避孕临床效果分别为89.13%、88.29%,服药后副反应小,无需处理。月经提前率为11%和22%,延迟率为17%和12%。统计学上无明显差异。结论两种小剂量米非司酮用于紧急避孕安全有效地防止意外妊娠。

A Clinical Observation on Different Does of Mifepristone for Emergency Contraception

Objective To evaluate the emergency contraceptive efficacy, the side effects and the influence to the next menstruation of two different low does of mifepristone. Methods 200healthy women with regular cycles and history were recruited within 72hours after unprotected intercourse or contraceptivefaiture, and they were randomly allocated into two groups. Group I mifepristone 50mg was given orally and groupII 25mg. Following-up visit was paid to evaluate the contraceptive efficacy and to record its side effects and menstruation. Results The emergency contraceptive effctiveness rate were 89.13%, 88.29% respectively and the side effects were slight and tolerable. The percentage of subjects who had a early onset of menses was 11%, 22% respectively and those who had a late one was 17%, 12% respectively. There was no statistically difference between the two groups. Conclusion Using of the two different low does of mifepristone for emergency contraception is effective and safe.